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Emerging drugs to target lower urinary tract symptomatology (LUTS)/benign prostatic hyperplasia (BPH): focus on the prostate

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Abstract

Objectives

The benign prostatic syndrome, comprising lower urinary tract symptomatology secondary to benign prostatic hyperplasia/enlargement, represents a major health care issue in westernized countries. The pharmacological management involves alpha-adrenoceptor antagonists, intervention into the hormonal control of prostate growth using inhibitors of the enzyme 5-alpha-reductase, and stimulation of the nitric oxide/cyclic GMP pathway by tadalafil, an inhibitor of the phosphodiesterase type 5.

Methods

This review summarizes the achievements which have been made in the development of drug candidates assumed to offer opportunities as beneficial treatment options in the management of the benign prostatic syndrome.

Results

A review of the literature has revealed that the line of development is focusing on drugs interfering with peripheral neuromuscular/neuronal mechanisms (nitric oxide donor drugs, agonists/antagonists of endogenous peptides, botulinum toxin, NX-1207), the steroidal axis (cetrorelix) or the metabolic turn-over (lonidamine), as well as the combination of drugs already established in the treatment of lower urinary tract symptomatology/benign prostatic hyperplasia (phosphodiesterase 5 inhibitor plus alpha-adrenoceptor antagonist).

Conclusion

Many research efforts have provided the basis for the development of new therapeutic modalities for the management of lower urinary tract dysfunctions, some of which might be offered to the patients in the near future.

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Authors and Affiliations

  1. Division of Surgery, Department of Urology and Urological Oncology, Hannover Medical School, 30623, Hannover, Germany

    Stefan Ückert, George T. Kedia & Markus A. Kuczyk

  2. Core Unit Proteomics, Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany

    Dimitrios Tsikas

  3. Department of Internal Medicine, Hannover Medical School, Hannover, Germany

    Annika Simon

  4. Department of Urology, Imland Klinik GmbH, Rendsburg, Germany

    Andreas Bannowsky

Authors
  1. Stefan Ückert
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  2. George T. Kedia
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  3. Dimitrios Tsikas
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  4. Annika Simon
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  5. Andreas Bannowsky
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  6. Markus A. Kuczyk
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Contributions

SÜ: data collection, manuscript writing. GTK: data collection, manuscript writing. DT: data collection/analysis, manuscript editing. AS: data collection, manuscript writing. AB: data collection/analysis. MAK: manuscript editing.

Corresponding author

Correspondence to Stefan Ückert.

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Ückert, S., Kedia, G.T., Tsikas, D. et al. Emerging drugs to target lower urinary tract symptomatology (LUTS)/benign prostatic hyperplasia (BPH): focus on the prostate. World J Urol 38, 1423–1435 (2020). https://doi.org/10.1007/s00345-019-02933-1

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