World Journal of Urology

, Volume 36, Issue 8, pp 1233–1239 | Cite as

Association between race and oncologic outcome following radical prostatectomy for clinically organ-confined prostate cancer: a long-term follow-up study

  • Erfan Amini
  • Tracy Campanelli Palmer
  • Jie Cai
  • Gary Lieskovsky
  • Siamak Daneshmand
  • Hooman Djaladat
Original Article



Few studies have evaluated prostate cancer oncologic outcomes in different ethnic groups following radical prostatectomy for clinically organ-confined disease. Existing studies lack long-term outcome data. We conducted this study to assess the impact of racial differences on risk profile and oncologic outcomes in a large cohort of patients with prostate cancer who underwent radical prostatectomy.


Using our institutional review board-approved prostate cancer database, we retrospectively reviewed the records of 3437 patients who underwent radical prostatectomy with curative intent in our institution between 1987 and 2009. Based on ethnicity, patients were divided into Asian Americans (n = 133), African Americans (n = 155) and Caucasians (n = 3149). Baseline characteristics and oncologic outcomes including biochemical recurrence free, clinical recurrence free and overall survival were compared between the study groups.


A total of 3437 patients with a mean age of 63 ± 9.8 years and median follow-up period of 8.7 (range 0.1–24.1) years were included in the analysis. Pathologic stage and the frequency of poorly differentiated cancer were higher in Asian Americans; however, margin status did not differ significantly. Moreover, oncologic outcomes were comparable between different ethnic groups. In multivariate analysis, both pathologic stage and grade were independent predictors of oncologic outcomes, but race was not.


In this large, ethnically diverse long-term follow-up study, we noted that Asian Americans compared to African Americans and Caucasians are more likely to have high risk prostate cancer; however, race was not an independent predictor of oncologic outcome following radical prostatectomy with curative intent.


Ethnic groups Prostatic neoplasms Race Recurrence Survival 


Authors’ contribution

EA, TCP, JC and HD were involved in project development and statistical analysis. EA, GL, SD and HD were involved in manuscript writing/editing. EA, TCP, JC, GL, SD and HD were involved in data management.

Compliance with ethical standards

Conflict of interest

Nothing to disclose.

Ethical approval

All patients included in this study had provided informed consent.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.The Institute of Urology, Norris Comprehensive Cancer CenterUniversity of Southern CaliforniaLos AngelesUSA
  2. 2.Department of Urology, Uro-oncology Research CenterTehran University of Medical SciencesTehranIran

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