Long-term oncological outcomes after robotic partial nephrectomy for renal cell carcinoma: a prospective multicentre study
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This study aimed at reporting the long-term oncological outcomes of robotic partial nephrectomy (RPN) for renal cell carcinoma (RCC).
Data from all consecutive patients who underwent RAPN for RCC from July 2009 to January 2012 in three departments of urology were prospectively collected. Overall survival (OS), cancer-specific survival (CSS) and disease free-survival (DFS) were estimated using the Kaplan–Meier method. Prognostic factors associated with CSS were sought in univariate analysis. The log-rank test was used for categorical variables and the Cox model for continuous variables.
110 patients were included with a median follow-up of 64.4 months [95% CI = (61.0–66.7)]. Median age was 61 years (29–83) with 62.7% of men and 37.3% of women. Median RENAL score was 6 (4–10) with elective indications accounting for 95% of cases. Out of 27 patients (24.5%) who experienced peri-operative complication, 12 patients (10.9%) had a major complication (Clavien-Dindo grade ≥ 3). The TRIFECTA achievement rate was 52.7%. Three patients (2.7%) experienced local recurrence and seven patients (6.4%) progressed to a metastatic disease. 5-year OS, CSS, DFS were 94.9, 96.8, 86.4%, respectively. In univariate analysis, no pre/peri-operative characteristic was associated with DFS. No port-site metastasis was observed and there was one case of peritoneal carcinomatosis.
In this multicenter series, long-term OS, DFS and CSS after RPN appeared comparable to large series of open partial nephrectomy, with no port-site metastasis and one case of peritoneal carcinomatosis.
KeywordsPartial nephrectomy Kidney neoplasm Long-term Oncology
JBB: Protocol/project development, Data analysis, Manuscript writing/editing. BP: Protocol/project development, Data analysis, Manuscript writing/editing. TB: Data collection or management, Data analysis. BC: Data analysis. TS: Manuscript writing/editing. MR: Protocol/Project development. BP: Data collection or management, Data analysis. ZEK: Data collection or management, Manuscript writing/editing. QM: Data collection or management. GV: Manuscript writing/editing. MT: Manuscript writing/editing. JP: Data collection or management. ND: Manuscript writing/editing. RM: Protocol/Project development. CV: Data collection or management, Data analysis. MS: Protocol/project development, Data analysis, Manuscript writing/editing. MR: Data collection or management, Data analysis, Manuscript writing/editing. KB: Manuscript writing/editing, Protocol/project development, Data collection or management, Data analysis.
Compliance with ethical standards
Conflict of interest
Karim Bensalah, Christophe Vaessen, Nicolas Doumerc and Gregory Verhoest are proctors for Intuitive Surgical®. Other authors declare that they have no conflict of interest.
All participants have given informed consent before inclusion in the present study.