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Remote brain microhaemorrhages may predict haematoma in glioma patients treated with radiation therapy

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Abstract

Objectives

To evaluate the prevalence of cerebral remote microhaemorrhages (RMH) and remote haematomas (RH) using magnetic resonance susceptibility-weighted imaging (SWI) among patients treated for gliomas during follow-up.

Methods

We conducted a retrospective single centre longitudinal study on 58 consecutive patients treated for gliomas from January 2009 through December 2010. Our institutional review board approved this study. We evaluated the presence and number of RMH and RH found outside the brain tumour on follow-up MR imaging. We performed univariate and bivariate analyses to identify predictors for RMH and RH and Kaplan–Meier survival analysis techniques.

Results

Twenty-five (43%) and four patients (7%) developed at least one RMH or RH, respectively, during follow-up. The risk was significantly higher for patients who received radiation therapy (49% and 8% versus 0%) (p = 0.02). The risk of developing RH was significantly higher in patients with at least one RMH and a high burden of RMH. The mean age of those presenting with at least one RMH or RH was significantly lower.

Conclusions

RMH were common in adult survivors of gliomas who received radiation therapy and may predict the onset of RH during follow-up, mainly in younger patients.

Key Points

• Brain RMH and RH are significantly more likely to occur after RT.

• RMH occur in almost half of the patients treated with RT.

• RMH and RH are significantly more frequent in younger patients.

• RH occur only in patients with RMH.

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Abbreviations

MH:

Microhaemorrhage

MR:

Magnetic resonance

RH:

Remote haematoma

RMH:

Remote microhaemorrhage

RT:

Radiation therapy

SWI:

Susceptibility-weighted imaging

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Acknowledgements

Laura McMaster provided professional English-language medical editing of this article.

Funding

The authors state that this work has not received any funding.

Author information

Authors and Affiliations

  1. Department of Radiology, Fondation Ophtalmologique Adolphe de Rothschild, 25 rue Manin, 75019, Paris, France

    Augustin Lecler, Frédérique Charbonneau & Julien Savatovsky

  2. Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France

    Dimitri Psimaras

  3. Clinical Research Unit, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France

    Marie-Astrid Metten

  4. Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France

    Antoine Gueguen

  5. Department of Neurooncology, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France

    Khe Hoang Xuan

  6. Department of Radiotherapy, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris, France

    Loic Feuvret

  7. Imagerie Medicale Paris 13, Paris, France

    Julien Savatovsky

Authors
  1. Augustin Lecler
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  2. Frédérique Charbonneau
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  3. Dimitri Psimaras
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  4. Marie-Astrid Metten
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  5. Antoine Gueguen
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  6. Khe Hoang Xuan
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  7. Loic Feuvret
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  8. Julien Savatovsky
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Corresponding author

Correspondence to Augustin Lecler.

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Guarantor

The scientific guarantor of this publication is Augustin Lecler.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

One of the authors has significant statistical expertise.

Informed consent

Written informed consent was waived by the Institutional Review Board.

Ethical approval

Our institutional review board approved this study and waived the informed consent requirement due to its retrospective nature.

Methodology

• retrospective

• observational study

• performed at one institution

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Lecler, A., Charbonneau, F., Psimaras, D. et al. Remote brain microhaemorrhages may predict haematoma in glioma patients treated with radiation therapy. Eur Radiol 28, 4324–4333 (2018). https://doi.org/10.1007/s00330-018-5356-8

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  • DOI: https://doi.org/10.1007/s00330-018-5356-8

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