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European Radiology

, Volume 28, Issue 10, pp 4324–4333 | Cite as

Remote brain microhaemorrhages may predict haematoma in glioma patients treated with radiation therapy

  • Augustin Lecler
  • Frédérique Charbonneau
  • Dimitri Psimaras
  • Marie-Astrid Metten
  • Antoine Gueguen
  • Khe Hoang Xuan
  • Loic Feuvret
  • Julien Savatovsky
Neuro

Abstract

Objectives

To evaluate the prevalence of cerebral remote microhaemorrhages (RMH) and remote haematomas (RH) using magnetic resonance susceptibility-weighted imaging (SWI) among patients treated for gliomas during follow-up.

Methods

We conducted a retrospective single centre longitudinal study on 58 consecutive patients treated for gliomas from January 2009 through December 2010. Our institutional review board approved this study. We evaluated the presence and number of RMH and RH found outside the brain tumour on follow-up MR imaging. We performed univariate and bivariate analyses to identify predictors for RMH and RH and Kaplan–Meier survival analysis techniques.

Results

Twenty-five (43%) and four patients (7%) developed at least one RMH or RH, respectively, during follow-up. The risk was significantly higher for patients who received radiation therapy (49% and 8% versus 0%) (p = 0.02). The risk of developing RH was significantly higher in patients with at least one RMH and a high burden of RMH. The mean age of those presenting with at least one RMH or RH was significantly lower.

Conclusions

RMH were common in adult survivors of gliomas who received radiation therapy and may predict the onset of RH during follow-up, mainly in younger patients.

Key Points

• Brain RMH and RH are significantly more likely to occur after RT.

• RMH occur in almost half of the patients treated with RT.

• RMH and RH are significantly more frequent in younger patients.

• RH occur only in patients with RMH.

Keywords

Magnetic resonance imaging Diagnostic imaging Radiation effects Radiotherapy Intracranial haemorrhages 

Abbreviations

MH

Microhaemorrhage

MR

Magnetic resonance

RH

Remote haematoma

RMH

Remote microhaemorrhage

RT

Radiation therapy

SWI

Susceptibility-weighted imaging

Notes

Acknowledgements

Laura McMaster provided professional English-language medical editing of this article.

Funding

The authors state that this work has not received any funding.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Augustin Lecler.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

One of the authors has significant statistical expertise.

Informed consent

Written informed consent was waived by the Institutional Review Board.

Ethical approval

Our institutional review board approved this study and waived the informed consent requirement due to its retrospective nature.

Methodology

• retrospective

• observational study

• performed at one institution

Supplementary material

330_2018_5356_MOESM1_ESM.docx (742 kb)
ESM 1 (DOCX 742 kb)

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Copyright information

© European Society of Radiology 2018

Authors and Affiliations

  1. 1.Department of RadiologyFondation Ophtalmologique Adolphe de RothschildParisFrance
  2. 2.Department of NeurologyGroupe Hospitalier Pitié-Salpêtrière, AP-HPParisFrance
  3. 3.Clinical Research UnitFondation Ophtalmologique Adolphe de RothschildParisFrance
  4. 4.Department of NeurologyFondation Ophtalmologique Adolphe de RothschildParisFrance
  5. 5.Department of NeurooncologyGroupe Hospitalier Pitié-Salpêtrière, AP-HPParisFrance
  6. 6.Department of RadiotherapyGroupe Hospitalier Pitié-Salpêtrière, AP-HPParisFrance
  7. 7.Imagerie Medicale Paris 13ParisFrance

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