Glypican-1 circulating exosomes: a promising clue to individualize surveillance of pancreatic cysts?

  • Pedro Moutinho-Ribeiro
  • Sonia Melo
  • Guilherme Macedo
Hepatobiliary-Pancreas
  • 11 Downloads

Notes

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Guilherme Macedo, PhD., Department of Gastroenterology, Centro Hospitalar São João, Porto, Portugal.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

No complex statistical methods were necessary for this paper.

Informed consent

Written informed consent was obtained from all subjects (patients) in this study.

Ethical approval

Institutional Review Board approval was obtained.

Methodology

• performed at one institution

References

  1. 1.
    Imbe K, Nagata N, Hisada Y et al (2018) Validation of the American Gastroenterological Association guidelines on management of intraductal papillary mucinous neoplasms: more than 5 years of follow-up. Eur Radiol 28:170–178.  https://doi.org/10.1007/s00330-017-4966-x CrossRefPubMedGoogle Scholar
  2. 2.
    Vege SS, Ziring B, Jain R et al (2015) American gastroenterological association institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts. Gastroenterology 148:819–822CrossRefPubMedGoogle Scholar
  3. 3.
    Tanaka M, Fernandez-del Castillo C, Adsay V et al (2012) International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology 12:183–197CrossRefPubMedGoogle Scholar
  4. 4.
    Del Chiaro M, Verbeke C, Salvia R et al (2014) European experts consensus statement on cystic tumours of the pancreas. Dig Liver Dis 45:703–711CrossRefGoogle Scholar
  5. 5.
    Crippa S, Pezzilli R, Bissolati M et al (2017) Active surveillance beyond 5 years is required for presumed branch-duct intraductal papillary mucinous neoplasms undergoing non-operative management. Am J Gastroenterol 112:1153–1161CrossRefPubMedGoogle Scholar
  6. 6.
    Farrell JJ (2017) Stopping pancreatic cyst surveillance? Am J Gastroenterol 112:1162–1164CrossRefPubMedGoogle Scholar
  7. 7.
    Singh H, McGrath K, Singhi AD (2017) Novel biomarkers for pancreatic cysts. Dig Dis Sci 62:1796–1807CrossRefPubMedGoogle Scholar
  8. 8.
    Melo SA, Luecke LB, Kahlert C et al (2015) Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature 523:177–182CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© European Society of Radiology 2018

Authors and Affiliations

  1. 1.Department of GastroenterologyCentro Hospitalar São JoãoPortoPortugal
  2. 2.Faculty of MedicineUniversity of PortoPortoPortugal
  3. 3.Instituto de Investigação e Inovação em Saúde (i3S)University of PortoPortoPortugal
  4. 4.Institute of Pathology and Molecular Immunology of the University of Porto (IPATIMUP)PortoPortugal

Personalised recommendations