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European Radiology

, Volume 28, Issue 7, pp 2735–2742 | Cite as

What are the predictors of clinical success after percutaneous vertebroplasty for osteoporotic vertebral fractures?

  • Elsa Denoix
  • Flore Viry
  • Agnes Ostertag
  • Caroline Parlier-Cuau
  • Jean-Denis Laredo
  • Martine Cohen-Solal
  • Valérie Bousson
  • Thomas Funck-Brentano
Interventional

Abstract

Objectives

Osteoporotic vertebral fractures are responsible for acute pain and disability that may persist for more than 2 months. We wanted to identify predicting factors for mid-term outcome after vertebroplasty.

Methods

We included consecutive patients who underwent vertebroplasty for fragility fractures with persistent and intense pain between January 2014–June 2016. Outcome was assessed by an independent clinician after 1 month using a standardized questionnaire. Patients were classified as having either a favorable or a poor outcome. Presence of an intravertebral cleft and bone oedema mean signal intensity was assessed by an independent radiologist blinded to the clinical data. Pre-intervention clinical or radiological factors were analysed as predictors for outcome.

Results

In the 78 included patients (females 71%, age 75 ± 8.3 years), 61.5% had a favourable outcome. When vertebroplasty was performed within 2 months after fracture, the outcome was favourable in 19 patients (39.6%) and poor in five (16.7%; estimate for favourable outcome: OR = 4.1, 95% CI 1.2–13.8, p = 0.021). Absence of intravertebral cleft on pre-intervention imaging was also a predictor of favourable outcome (OR = 3.7, 95% CI 1.2–11.8, p = 0.024). On pre-intervention MRI, vertebral body oedema intensity signal did not influence the outcome.

Conclusions

In patients with persistent and intense pain after an osteoporotic vertebral fracture, early intervention and absence of intravertebral cleft were predictors of favourable outcome at 1 month after vertebroplasty.

Key Points

• Performing vertebroplasty within 2 months following a fragility fracture increases success rate.

• Presence of an intravertebral cleft at baseline is a predictor of poor mid-term outcome.

• A pre-intervention MRI should be performed to ascertain the indication of vertebroplasty.

Keywords

Vertebroplasty Fractures, compression Osteoporotic fractures Treatment outcome Pain measurement 

Abbreviations

CI

Confidence interval

L

Lumbar

OR

Odds ratio

SD

Standard deviation

Th

Thoracic

Notes

Acknowledgements

We are grateful to Pr. Philippe Orcel and Pr. Pascal Richette for their advice and to Dr. Bassam Hamze who performed part of the interventions.

Funding

The authors state that this work has not received any funding.

Compliance with ethical standards

Guarantor

The scientific guarantor of this publication is Dr Thomas Funck-Brentano.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

Dr. Agnès Ostertag has significant statistical expertise.

Informed consent

Written informed consent was obtained from all patients in this study.

Ethical approval

Institutional Review Board approval was not required because it was an observational study to evaluate a standard-care procedure, and not an intervention study.

Methodology

• Retrospective with prospective outcome assessment

• Observational

• Performed at one institution

Supplementary material

330_2017_5274_MOESM1_ESM.docx (18 kb)
ESM 1 (DOCX 17 kb)

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Copyright information

© European Society of Radiology 2018

Authors and Affiliations

  1. 1.Department of RheumatologyAP-HP, Lariboisière Teaching HospitalParisFrance
  2. 2.Department of Musculoskeletal RadiologyAP-HP, Lariboisière Teaching HospitalParisFrance
  3. 3.BIOSCAR UMRS 1132, Université Paris Diderot, Sorbonne Paris Cité, INSERMParisFrance
  4. 4.B2OA UMR 7052, Université Paris Diderot, Sorbonne Paris Cité, CNRSParisFrance

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