Intravoxel incoherent motion MR imaging of early cervical carcinoma: correlation between imaging parameters and tumor-stroma ratio
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To investigate if intravoxel incoherent motion (IVIM) MR imaging can predict the tumour-stroma ratio (TSR) in patients with early cervical carcinoma.
Fifty-four patients with early cervical carcinoma were prospectively enrolled into this study. All patients underwent IVIM imaging and parameters including D, D* and f value were measured. The tumours were classified into stroma-rich and stroma-poor group according to TSR, and comparisons of IVIM parameters between two groups were performed. The relationships between IVIM parameters and TSR were analysed by using a multivariate multi-regression analysis.
D and f values were significantly lower in stroma-poor tumours than in stroma-rich tumours (p=0.02, 0.04), while the difference in D* value between two groups didn't achieve statistical significance (p=0.09). The areas under ROC curves of D and f values in discriminating stroma-rich and stroma-poor tumours were 0.835 (95%CI=0.616~0.905) and 0.686 (95%CI=0.575~0.798). In multiple linear regression analysis, D value, pathologic type, histologic grade, tumour size and f value were independently correlated with TSR of cervical carcinoma.
D and f values are independently correlated with TSR of cervical carcinoma and have the potential for quantitative measurement of TSR.
• TSR is a recognized independent prognostic factor in many solid tumours.
• D and f values measured by IVIM MRI are independently correlated with TSR while D* is not.
• IVIM offers the potential to predict TSR.
KeywordsDiffusion Magnetic Resonance Imaging Uterine Cervical Neoplasms Stromal Cells Intravoxel incoherent motion Tumor-stroma ratio
The authors state that this work has not received any funding.
Compliance with ethical standards
The scientific guarantor of this publication is Li Xiang Sheng, M.D. and Yu Tao, M.D.
Conflict of interest
The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.
Statistics and biometry
No complex statistical methods were necessary for this paper.
Written informed consent was obtained from all subjects (patients) in this study.
Institutional Review Board approval was obtained.
• diagnostic study / observational
• performed at one institution
- 5.Gremonprez F, Descamps B, Izmer A et al (2015) Pretreatment with VEGF(R)-inhibitors reduces interstitial fluid pressure, increases intraperitoneal chemotherapy drug penetration, and impedes tumour growth in a mouse colorectal carcinomatosis model. Oncotarget 6:29889–29900CrossRefPubMedPubMedCentralGoogle Scholar
- 8.Roeke T, Sobral-Leite M, Dekker TJA (2017) The prognostic value of the tumour-stroma ratio in primary operable invasive cancer of the breast: a validation study. Breast Cancer Res Treat. https://doi.org/10.1007/s10549-017-4445-8
- 27.Wang YC, Hu S, Hu XM et al (2015) Intravoxel incoherent motion magnetic resonance imaging for diagnosis of cervical cancer and evaluation of response of uterine cervical cancer to radiochemotherapy: a pilot study. Oncology and Translational Medicine 1:P164–P170Google Scholar