Magnetic Resonance Parkinsonism Index: diagnostic accuracy of a fully automated algorithm in comparison with the manual measurement in a large Italian multicentre study in patients with progressive supranuclear palsy
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To investigate the reliability of a new in-house automatic algorithm for calculating the Magnetic Resonance Parkinsonism Index (MRPI), in a large multicentre study population of patients affected by progressive supranuclear palsy (PSP) or Parkinson’s disease (PD), and healthy controls (HC), and to compare the diagnostic accuracy of the automatic and manual MRPI values.
The study included 88 PSP patients, 234 PD patients and 117 controls. MRI was performed using both 3T and 1.5T scanners. Automatic and manual MRPI values were evaluated, and accuracy of both methods in distinguishing PSP from PD and controls was calculated.
No statistical differences were found between automated and manual MRPI values in all groups. The automatic MRPI values differentiated PSP from PD with an accuracy of 95 % (manual MRPI accuracy 96 %) and 97 % (manual MRPI accuracy 100 %) for 1.5T and 3T scanners, respectively.
Our study showed that the new in-house automated method for MRPI calculation was highly accurate in distinguishing PSP from PD. Our automatic approach allows a widespread use of MRPI in clinical practice and in longitudinal research studies.
• A new automatic method for calculating the MRPI is presented.
• Automatic MRPI values are in good agreement with manual values.
• Automatic MRPI can distinguish patients with PSP from patients with PD.
• The automatic method overcomes MRPI application limitations in routine practice.
• The automatic method may allow a more widespread use of MRPI.
KeywordsMagnetic Resonance Parkinsonism Index Progressive supranuclear palsy Parkinson’s disease Automatic segmentation Neurodegenerative disease
Middle cerebellar peduncle
Magnetic Resonance Parkinsonism Index
Progressive supranuclear palsy
Receiver operating characteristic
Superior cerebellar peduncle
The scientific guarantor of this publication is Professor Aldo Quattrone. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: cross sectional study, multicentre study.
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