Ethanolgel sclerotherapy of venous malformations improves health-related quality-of-life in adults and children – results of a prospective study
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To assess the treatment-induced changes of health-related quality-of-life (HRQoL) in patients with venous malformations (VM) who underwent ethanol gel sclerotherapy.
The prospective study in children and adults was approved by the local ethics committee. 31 patients (mean age 23.42 years, range 6.6 – 46.5; 26 female, 5 male) with VM were included. Patients’ self-assessed HRQoL was measured before and after treatment using psychometrically validated questionnaires for adults and children. Differences were analysed with a paired t test.
58 sclerotherapy sessions were performed. The Physical Component Summary (PCS) at baseline was 43.69 and increased significantly (p = 0.01122) to 48.95 after treatment. The bodily pain (BP) scale increased significantly from 37.94 to 48.56 (p = 0.00002), the general health (GH) scale increased significantly from 46.69 to 52.17 (p = 0.00609). Baseline Physical Summary Score (PHS) in children increased significantly after treatment (p < 0.00001) from 25.25 to 45.89. The baseline Psychosocial Summary Score (PSS) in children was 51.08 and increased significantly (p = 0.00031) after treatment to 58.84.
Paediatric and adult patients with VM suffer from bodily pain with overall reduced physical functioning. After sclerotherapy, these restrictions are successfully returning to normal levels with a positive effect on mental and psychosocial domains.
• Sclerotherapy in venous malformation patients has an unknown effect on health-related quality-of-life
• Prospective study showed improvements in bodily pain and general health in adults
• Children and adults improved from treatment with ethanol gel
• Sclerotherapy is an appropriate therapy
KeywordsVascular malformation Sclerotherapy Quality of life Children Adults
The scientific guarantor of this publication is WAW. WAW, WU and RMW declare relationships with the following companies: ab medica, Düsseldorf, Germany (lecturing, proctoring). The authors state that this work has not received any funding. WAW has significant statistical expertise. Institutional review board approval from the Ethikkommission an der Universität Regensburg was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective, longitudinal study, performed at one institution.
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