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European Radiology

, Volume 27, Issue 6, pp 2546–2553 | Cite as

Technical feasibility and tissue reaction after silicone-covered biodegradable magnesium stent insertion in the oesophagus: a primary study in vitro and in vivo

  • Yue-Qi Zhu
  • Laura Edmonds
  • Li-Ming Wei
  • Rei-La Zheng
  • Ruo-Yu Cheng
  • Wen-Guo Cui
  • Ying-Sheng Cheng
Gastrointestinal

Abstract

Objectives

Determine the feasibility of and tissue response to biodegradable magnesium–silicone stent insertion into the oesophagus of rabbits.

Methods

Mechanical compression–recovery and degradation behaviours of the stents were investigated in vitro. Thirty rabbits were randomly divided into a magnesium–silicone stent group (n = 15) that received stent insertion into the lower 1/3 of the oesophagus under fluoroscopic guidance and a control group (n = 15). Oesophagography was performed at 1, 2 and 4 weeks. Five rabbits in each group were euthanized at each time point for histological examination.

Results

Magnesium–silicone stents showed good flexibility and elasticity, and degraded more slowly than bare stents at pH 4.0 and 7.4. All stent insertions were well tolerated. The oesophageal diameters at 1, 2 and 4 weeks were 9.7 ± 0.7, 9.6 ± 0.8 and 9.6 ± 0.5 mm, respectively (vs. 9.2 ± 0.8 mm before intervention; P > 0.05). Stent migration occurred in six rabbits (one at 1 week, one at 2 and four at 4). Microscopy demonstrated dilation of the oesophageal wall within 1 week of insertion. Oesophageal injury and collagen deposition following stent insertion were similar to control (P > 0.05).

Conclusions

Oesophageal magnesium–silicone stent insertion was feasible and provided reliable support for 2 weeks without causing oesophageal injury or collagen deposition.

Key Points

Mg stent provided apparently adequate radial force and silicone membrane reduced magnesium biodegradation

Stent insertion provided good support for at least 2 weeks before biodegradation

Stenting effectively resulted in oesophageal wall remodelling, without demonstrable injury.

Keywords

Stent Biodegradation Magnesium Oesophagus Interventional radiology 

Notes

Acknowledgments

The scientific guarantor of this publication is CYS. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study has received funding by the National Natural Science Foundation of China (no.81371659, 8117137, 81370041, 51373112), Jiangsu Provincial Special Program of Medical Science (BL2012004), Jiangsu Provincial Clinical Orthopedic Center, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). No complex statistical methods were necessary for this paper. Institutional review board approval was obtained. Approval from the institutional animal care committee was obtained. Methodology: prospective, experimental, performed at one institution.

Supplementary material

330_2016_4602_MOESM1_ESM.doc (30 kb)
Supplementary Table 1 (DOC 30 kb)

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Copyright information

© European Society of Radiology 2016

Authors and Affiliations

  • Yue-Qi Zhu
    • 1
  • Laura Edmonds
    • 2
    • 3
  • Li-Ming Wei
    • 1
  • Rei-La Zheng
    • 2
  • Ruo-Yu Cheng
    • 2
  • Wen-Guo Cui
    • 2
  • Ying-Sheng Cheng
    • 1
  1. 1.Department of RadiologyShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina
  2. 2.Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic InstituteSoochow UniversitySuzhouPeople’s Republic of China
  3. 3.Nanotechnology EngineeringUniversity of WaterlooWaterlooCanada

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