Technical feasibility and tissue reaction after silicone-covered biodegradable magnesium stent insertion in the oesophagus: a primary study in vitro and in vivo
Determine the feasibility of and tissue response to biodegradable magnesium–silicone stent insertion into the oesophagus of rabbits.
Mechanical compression–recovery and degradation behaviours of the stents were investigated in vitro. Thirty rabbits were randomly divided into a magnesium–silicone stent group (n = 15) that received stent insertion into the lower 1/3 of the oesophagus under fluoroscopic guidance and a control group (n = 15). Oesophagography was performed at 1, 2 and 4 weeks. Five rabbits in each group were euthanized at each time point for histological examination.
Magnesium–silicone stents showed good flexibility and elasticity, and degraded more slowly than bare stents at pH 4.0 and 7.4. All stent insertions were well tolerated. The oesophageal diameters at 1, 2 and 4 weeks were 9.7 ± 0.7, 9.6 ± 0.8 and 9.6 ± 0.5 mm, respectively (vs. 9.2 ± 0.8 mm before intervention; P > 0.05). Stent migration occurred in six rabbits (one at 1 week, one at 2 and four at 4). Microscopy demonstrated dilation of the oesophageal wall within 1 week of insertion. Oesophageal injury and collagen deposition following stent insertion were similar to control (P > 0.05).
Oesophageal magnesium–silicone stent insertion was feasible and provided reliable support for 2 weeks without causing oesophageal injury or collagen deposition.
• Mg stent provided apparently adequate radial force and silicone membrane reduced magnesium biodegradation
• Stent insertion provided good support for at least 2 weeks before biodegradation
• Stenting effectively resulted in oesophageal wall remodelling, without demonstrable injury.
KeywordsStent Biodegradation Magnesium Oesophagus Interventional radiology
The scientific guarantor of this publication is CYS. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study has received funding by the National Natural Science Foundation of China (no.81371659, 8117137, 81370041, 51373112), Jiangsu Provincial Special Program of Medical Science (BL2012004), Jiangsu Provincial Clinical Orthopedic Center, the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). No complex statistical methods were necessary for this paper. Institutional review board approval was obtained. Approval from the institutional animal care committee was obtained. Methodology: prospective, experimental, performed at one institution.
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