Non-invasive imaging of myocardial bridge by coronary computed tomography angiography: the value of transluminal attenuation gradient to predict significant dynamic compression
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To study the diagnostic value of transluminal attenuation gradient (TAG) measured by coronary computed tomography angiography (CCTA) for identifying relevant dynamic compression of myocardial bridge (MB).
Patients with confirmed MB who underwent both CCTA and ICA within one month were retrospectively included. TAG was defined as the linear regression coefficient between luminal attenuation and distance. The TAG of MB vessel, length and depth of MB were measured and correlated with the presence and degree of dynamic compression observed at ICA. Systolic compression ≧50 % was considered significant.
302 patients with confirmed MB lesions were included. TAG was lowest (-17.4 ± 6.7 HU/10 mm) in patients with significant dynamic compression and highest in patients without MB compression (-9.5 ± 4.3 HU/10 mm, p < 0.001). Linear correlation revealed relation between the percentage of systolic compression and TAG (Pearson correlation, r = -0.52, p < 0.001) and no significant relation between the percentage of systolic compression and MB depth or length. ROC curve analysis determined the best cut-off value of TAG as -14.8HU/10 mm (area under curve = 0.813, 95 % confidence interval = 0.764-0.855, p < 0.001), which yielded high diagnostic accuracy (82.1 %, 248/302).
The degree of ICA-assessed systolic compression of MB significantly correlates with TAG but not MB depth or length.
• TAG is associated with the extent of dynamic compression of MB.
• TAG is superior to depth and length for identifying dynamic compression.
• Cut-off value of TAG as -14.8HU/10 mm yielded high predictive value.
KeywordsCoronary artery disease Computed tomography Myocardial bridge Coronary angiography Transluminal attenuation gradient
Abbreviations and acronyms
Coronary computed tomography angiography
Curved planar reformation
Invasive coronary angiography
Left anterior descending
Percutaneous coronary intervention
Transluminal attenuation gradient
This study is funded by National Development Project of Key Clinical Department. The scientific guarantor of this publication is Dr. Jiayin Zhang. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. This study has received funding by National Natural Science Foundation of China (Grant No.: 81301219) and Shanghai Committee of Science and Technology, China (Grant No.: 13ZR1431500). No complex statistical methods were necessary for this paper. Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board. Methodology: retrospective, diagnostic or prognostic study, performed at one institution.
- 18.Wong DT, Ko BS, Cameron JD et al (2013) Transluminal attenuation gradient in coronary computed tomography angiography is a novel noninvasive approach to the identification of functionally significant coronary artery stenosis: a comparison with fractional flow reserve. J Am Coll Cardiol 61:1271–1279CrossRefPubMedGoogle Scholar
- 19.Wong DT, Ko BS, Cameron JD et al (2014) Comparison of diagnostic accuracy of combined assessment using adenosine stress computed tomography perfusion + computed tomography angiography with transluminal attenuation gradient + computed tomography angiography against invasive fractional flow reserve. J Am Coll Cardiol 63:1904–1912CrossRefPubMedGoogle Scholar