European Radiology

, Volume 27, Issue 5, pp 2110–2118 | Cite as

Volumetric MRI study of the intrauterine growth restriction fetal brain

  • A. Polat
  • S. Barlow
  • R. Ber
  • R. Achiron
  • E. Katorza
Magnetic Resonance

Abstract

Objectives

Intrauterine growth restriction (IUGR) is a pathologic fetal condition known to affect the fetal brain regionally and associated with future neurodevelopmental abnormalities. This study employed MRI to assess in utero regional brain volume changes in IUGR fetuses compared to controls.

Methods

Retrospectively, using MRI images of fetuses at 30–34 weeks gestational age, a total of 8 brain regions—supratentorial brain and cavity, cerebral hemispheres, temporal lobes and cerebellum—were measured for volume in 13 fetuses with IUGR due to placental insufficiency and in 21 controls. Volumes and their ratios were assessed for difference using regression models. Reliability was assessed by intraclass correlation coefficients (ICC) between two observers.

Results

In both groups, all structures increase in absolute volume during that gestation period, and the rate of cerebellar growth is higher compared to that of supratentorial structures. All structures’ absolute volumes were significantly smaller for the IUGR group. Cerebellar to supratentorial ratios were found to be significantly smaller (P < 0.05) for IUGR compared to controls. No other significant ratio differences were found. ICC showed excellent agreement.

Conclusions

The cerebellar to supratentorial volume ratio is affected in IUGR fetuses. Additional research is needed to assess this as a radiologic marker in relation to long-term outcome.

Key Points

• IUGR is a pathologic fetal condition affecting the brain

• IUGR is associated with long-term neurodevelopmental abnormalities; fetal characterization is needed

• This study aimed to evaluate regional brain volume differences in IUGR

• Cerebellar to supratentorial volume ratios were smaller in IUGR fetuses

• This finding may play a role in long-term development of IUGR fetuses

Keywords

Brain Cerebellum Embryonic and fetal development IUGR MRI 

Abbreviations

CER

Cerebellum

LH

Left cerebral hemisphere

LT

Left temporal lobe

RH

Right cerebral hemisphere

RT

Right temporal lobe

STB

Supratentorial brain

STC

Supratentorial cavity

TT

Total temporal lobes

Notes

Acknowledgments

The scientific guarantor of this publication is Dr. Eldad Katorza, Sheba Medical Center, Israel. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. Estela Derazne kindly provided statistical advice for this manuscript. Institutional review board approval was obtained. Written informed consent was waived by the institutional review board. Methodology: retrospective, case-control study, performed at one institution.

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Copyright information

© European Society of Radiology 2016

Authors and Affiliations

  • A. Polat
    • 1
  • S. Barlow
    • 1
  • R. Ber
    • 1
  • R. Achiron
    • 1
  • E. Katorza
    • 1
  1. 1.Department of Obstetrics and Gynecology, the Chaim Sheba Medical Center, Tel Hashomer, Affiliated with Sackler School of MedicineTel Aviv UniversityTel AvivIsrael

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