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Prevalence of other connective tissue diseases in idiopathic inflammatory myopathies

  • Observational Research
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Abstract

We sought to determine the prevalence of additional connective tissue diseases (CTDs) in patients with idiopathic inflammatory myopathies (IIM), and to study the muscle biopsy patterns in various clinico-serologic subsets of myositis. We undertook a retrospective cohort study of 648 patients with a histological diagnosis of IIM. The following was determined from the South Australian Myositis Database: presence of associated CTDs, histological details and presence of myositis-specific (MSA) or myositis-associated (MAA) antibodies. Among patients with IIM, a significantly greater proportion had systemic sclerosis 32/648 (4.9%) than mixed connective tissue disease (12/648, p = 0.003), primary Sjogren’s syndrome (12/648, p = 0.003), systemic lupus erythematosus (10/648, p < 0.001) or rheumatoid arthritis (6/648, p = 0.0001). Polymyositis was the most common IIM diagnosis regardless of the presence or absence of CTD. MSA/MAA was more commonly detected in those with systemic sclerosis than those with IIM alone (OR 5.35, p < 0.005). The higher prevalence of SSc (compared with other CTDs) in IIM, together with the more frequent detection of autoantibodies in this group, suggests that these conditions may be linked.

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Acknowledgements

The authors are grateful to the Department of Anatomical Pathology, SA Pathology and to all patients and physicians who have supported the South Australian Myositis Database.

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No specific funding was obtained for this research.

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Authors and Affiliations

  1. Rheumatologist, Rheumatology Tasmania, 4 Warneford St, Hobart, TAS, 7000, Australia

    Adam Maundrell

  2. Rheumatology Department, Royal Adelaide Hospital, Port Rd, Adelaide, SA, 5000, Australia

    Susanna Proudman & Vidya Limaye

  3. Discipline of Medicine, University of Adelaide, North Tce, Adelaide, SA, 5000, Australia

    Susanna Proudman & Vidya Limaye

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  1. Adam Maundrell
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  2. Susanna Proudman
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  3. Vidya Limaye
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Correspondence to Vidya Limaye.

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Maundrell, A., Proudman, S. & Limaye, V. Prevalence of other connective tissue diseases in idiopathic inflammatory myopathies. Rheumatol Int 39, 1777–1781 (2019). https://doi.org/10.1007/s00296-019-04411-8

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  • DOI: https://doi.org/10.1007/s00296-019-04411-8

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