Abstract
Since immune complexes (IC) are a direct product of immune response through the binding between antigen and antibody, the profile of antigen-associated ICs may depend on each autoimmune disease. In this report, we examined the similarity of four neurological autoimmune diseases, Alzheimer’s disease and healthy donors, and seven connective tissue diseases based on the profiling of IC-associated antigens which were previously or recently identified by immune complexome analysis of cerebrospinal fluid (CSF) or serum samples. The similarity between each pair of two diseases was assessed by correlation coefficients as distance matrix with the use of detection frequency (i.e., the percentage of patients who were positive for a certain antigen in each disease) of each IC-associated antigen in a certain disease. Among 15 pairs of five diseases and healthy control examined by the analysis of CSF samples, only 1 pair of neuropsychiatric systemic lupus erythematosus and multiple sclerosis corresponds to the higher correlation value (r = 0.73) than 0.7. On the other hand, among seven connective tissue diseases examined by the analysis of serum samples, 12 of 21 pairs show high correlation value (r > 0.70). Our finding suggested that the profile of IC-associated antigens identified by immune complexome analysis of CSF samples can be useful for evaluating the similarity of neurological autoimmune diseases; however, not by that of serum samples.
References
Kavai M, Szegedi G (2007) Immune complex clearance by monocytes and macrophages in systemic lupus erythematosus. Autoimmun Rev 6:497–502
Lubin R, Zalcman G, Bouchet L, Trédanel J, Legros Y, Cazals D et al (1995) Serum p53 antibodies as early markers of lung cancer. Nat Med 1:701–702
Ritzmann SE, Daniels JC (1982) Immune complexes: characteristics, clinical correlations, and interpretive approaches in the clinical laboratory. Clin Chem 28:1259–1271
Murphy BF, Kirszbaum L, Walker ID, d’Apice AJ (1988) Sp-40, 40, a new identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis. J Clin Invest 81:1858–1864
Nangaku M, Couser WG (2005) Mechanisms of immune-deposit formation and the mediation of immune renal injury. Clin Exp Nephrol 9:183–191
Ohyama K, Ueki Y, Kawakami A et al (2011) Immune complexome analysis of serum and its application in screening for immune complex antigens in rheumatoid arthritis. Clin Chem 57:905–909
Aibara N, Ichinose K, Baba M, Nakajima H, Satoh K, Atarashi R et al (2018) Proteomic approach to profiling immune complex antigens in cerebrospinal fluid samples from patients with central nervous system autoimmune diseases. Clin Chim Acta 484:26–31
Ohyama K, Baba M, Tamai M, Aibara N, Ichinose K, Kishikawa N et al (2015) Proteomic profiling of antigens in circulating immune complexes associated with each of seven autoimmune diseases. Clin Biochem 48:181–185
Lima I, Melo A, Brandi IV, Costa O, Santiago M (2007) Lupoid sclerosis: what is the role of antiphospholipid antibodies? J Clin Rheumatol 13:85–86
Hopia L, Thangarajh M, Khademi M, Laveskog A, Wallström E, Svenungsson E et al (2011) Cerebrospinal fluid levels of a proliferation-inducing ligand (APRIL) are increased in patients with neuropsychiatric systemic lupus erythematosus. Scand J Rheumatol 40:363–372
Brändle SM, Obermeier B, Senel M, Bruder J, Mentele R, Khademi M et al (2016) Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins. Proc Natl Acad Sci USA 113:7864–7869
Ichinose K, Ohyama K, Furukawa K, Higuchi O, Mukaino A, Satoh K et al (2018) Novel anti-suprabasin antibodies may contribute to the pathogenesis of neuropsychiatric systemic lupus erythematosus. Clin Immunol 193:123–130
Acknowledgements
We greatly acknowledge the support on the evaluation of similarity by Ms. Chihiro Miyazaki (KAN Research Institute, Japan). This work was supported by Grant-in-aid for Scientific Research (B) and (C) and Challenging Exploratory Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by Takeda Science Foundation.
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MB and KO analyzed the data and drafted the paper. KI, MT and AK designed and supervised the study.
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Baba, M., Ichinose, K., Tamai, M. et al. Similarity of autoimmune diseases based on the profile of immune complex antigens. Rheumatol Int 39, 323–325 (2019). https://doi.org/10.1007/s00296-018-4206-y
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DOI: https://doi.org/10.1007/s00296-018-4206-y