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Risk of hospitalization for heart failure in rheumatoid arthritis patients treated with etanercept and abatacept

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Abstract

To estimate biologic influence on heart failure (HF) risk in rheumatoid arthritis. Retrospective cohort (RECORD Study of Italian Society for Rheumatology) study on administrative healthcare databases. We identified 2527 patients treated with either etanercept (n = 1690) or abatacept (n = 837). HF incidence rate was higher in the abatacept cohort than in the etanercept cohort with a 2.38 (95% CI 1.08–5.27) crude competing risk HR (SHR) for abatacept of developing HF, not confirmed after adjustment for prespecified confounders (SHR 1.43; 95% CI 0.51–3.98). Abatacept, compared to etanercept, is prescribed to patients with a worse cardiovascular profile but does not increase the risk of developing HF, when confounding factors are accounted for.

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Authors and Affiliations

  1. Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, via A. Manzoni 56, Rozzano, 20089, Milan, Italy

    Elena Generali & Carlo Selmi

  2. Epidemiology Unit, Italian Society for Rheumatology, Milan, Italy

    Greta Carrara & Carlo A. Scirè

  3. Laboratory of Adaptive Immunity, Humanitas Clinical and Research Center, Milan, Italy

    Marinos Kallikourdis

  4. Humanitas University, Rozzano, Italy

    Marinos Kallikourdis & Gianluigi Condorelli

  5. Department of Cardiovascular Medicine, Humanitas Clinical and Research Center, Milan, Italy

    Gianluigi Condorelli

  6. University of Ferrara, Ferrara, Italy

    Alessandra Bortoluzzi & Carlo A. Scirè

  7. BIOMETRA Department, University of Milan, Milan, Italy

    Carlo Selmi

Authors
  1. Elena Generali
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  2. Greta Carrara
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  3. Marinos Kallikourdis
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  4. Gianluigi Condorelli
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  5. Alessandra Bortoluzzi
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  6. Carlo A. Scirè
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  7. Carlo Selmi
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Contributions

EG, GC, AB, CS, CAS, MK, GC designed the idea, designed and supervised the project. EG, CS, GC, CAS, AB contributed to data analysis. EG, GC, AB CS, CAS, MK, GC critically reviewed and provided valuable input. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Carlo Selmi.

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Conflict of interest

EG, GC, MK, GC, AB, CAS have none to declare; Carlo Selmi has been consulting for BMS and Pfizer.

Ethical approval

The present work was approved by IRB of University of Pavia, Italy (deliberation of 12/03/2012).

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Generali, E., Carrara, G., Kallikourdis, M. et al. Risk of hospitalization for heart failure in rheumatoid arthritis patients treated with etanercept and abatacept. Rheumatol Int 39, 239–243 (2019). https://doi.org/10.1007/s00296-018-4196-9

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  • DOI: https://doi.org/10.1007/s00296-018-4196-9

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