Skip to main content

Advertisement

SpringerLink
Log in

Circulating microparticles bearing Fibrin associated with whole-body 18FDG-PET: diagnostic tools to detect paraneoplastic polymyalgia rheumatica

  • Imaging
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

Polymyalgia rheumatica (PMR), a chronic inflammatory rheumatism, can be the expression of a paraneoplastic syndrome. The same clinical symptoms are frequently observed at the early stage of the benign and malignant forms. Here, our aim was to develop diagnostic tools to differentiate paraneoplastic PMR from essential PMR. We combined an 18FDG-PET and detection of circulating procoagulant microparticles (MPs), such as fibrin positive (FibMPs), by flow cytometry. Two patients with PMR and a similar profile were selected. In the two patients, the 18FDG-PET revealed a hypermetabolic focus. However, the concentrations of fibrin+/annexin+ microparticles detected were (10 times higher in one of the two patients, who was later found to have breast cancer. The association of 18FDG-PET and the detection of microparticle fibrin positives by flow cytometry allows separating essential PMR (hypermetabolism by 18FDG-PET, low FibMPs) from paraneoplastic PMR.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Fam AG (2000) Paraneoplastic rheumatic syndromes. Baillieres Best Pract Res Clin Rheumatol 14(3):515–533

    Article  CAS  PubMed  Google Scholar 

  2. Alias A, Rodriguez EJ, Bateman HE, Sterrett AG, Valeriano-Marcet J (2012) Rheumatology and oncology: an updated review of rheumatic manifestations of malignancy and anti-neoplastic therapy. Bull NYU Hosp Jt Dis 70(2):109–114

    PubMed  Google Scholar 

  3. Hakkou J, Rostom S, Bahiri R, Hajjaj-Hassouni N (2012) Paraneoplastic rheumatic syndromes: report of eight cases and review of literature. Rheumatol Int 32(6):1485–1489

    Article  PubMed  Google Scholar 

  4. Morel J, Deschamps V, Toussirot E, Pertuiset E, Sordet C, Kieffer P, Berthelot JM, Champagne H, Mariette X, Combe B (2008) Characteristics and survival of 26 patients with paraneoplastic arthritis. Ann Rheum Dis 67(2):244–247

    Article  CAS  PubMed  Google Scholar 

  5. Linke R, Voltz R (2008) FDG-pet in paraneoplastic syndromes. Recent Results Cancer Res 170:203–211

    Article  CAS  PubMed  Google Scholar 

  6. Cammilleri S, Guzian MC, Mattei JP, Mundler O, Guis S (2013) Whole-body (18) FDG-PET in an arthritis paraneoplastic syndrome revealed an underlying hematological neoplasm. Case Rep Med 594704

  7. Danve A, O’Dell J (2015) The role of 18Fluorodeoxyglucose positron emission tomography scanning in the diagnosis and management of systemic vasculitis. Int J Rheul Dis 18(7):714–724

    Article  CAS  Google Scholar 

  8. Lehman VT, Barrick BJ, Pittelkow MR, Peller PJ, Camilleri MJ, Lehman JS (2015) Diagnostic imaging in paraneoplastic autoimmune multiorgan syndrome: retrospective single site study and literature review of 225 patients. Int J Dermatol 54(4):424–437

    Article  CAS  PubMed  Google Scholar 

  9. Robert S, Lacroix R, Poncelet P, Harhouri K, Bouriche T, Judicone C, Wischhusen J, Arnaud L, Dignat-George F (2012) High-sensitivity flow cytometry provides access to standardized measurement of small-size microparticles–brief report. Arterioscler Thromb Vasc Biol 32(4):1054–1058

    Article  CAS  PubMed  Google Scholar 

  10. Piccin A, Murphy WG, Smith OP (2007) Circulating microparticles: pathophysiology and clinical implications. Blood Rev 21(3):157–171

    Article  CAS  PubMed  Google Scholar 

  11. Mezouar S, Darbousset R, Dignat-George F, Panicot-Dubois L, Dubois C (2015) Inhibition of platelet activation prevents the P-selectin and integrin-dependent accumulation of cancer cell microparticles and reduces tumor growth and metastasis in vivo. Int J Cancer 136(2):462–475

    Article  CAS  PubMed  Google Scholar 

  12. Mezouar S, Mege D, Darbousset R, Farge D, Debourdeau P, Dignat-George F, Panicot-Dubois L, Dubois C (2014) Involvement of platelet-derived microparticles in tumor progression and thrombosis. Semin Oncol 41(3):346–358

    Article  CAS  PubMed  Google Scholar 

  13. Kaplan RN, Rafii S, Lyden D (2006) Preparing the “soil”: the premetastatic niche. Cancer Res 66(23):11089–11093

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Geddings JE, Mackman N (2013) Tumor-derived tissue factor-positive microparticles and venous thrombosis in cancer patients. Blood 122(11):1873–1880

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Lacroix R, Judicone C, Poncelet P, Robert S, Arnaud L, Sampol J, Dignat-George F (2012) Impact of pre-analytical parameters on the measurement of circulating microparticles: towards standardization of protocol. J Thromb Haemost 10(3):437–446

    Article  CAS  PubMed  Google Scholar 

  16. Thomas GM, Panicot-Dubois L, Lacroix R, Dignat-George F, Lombardo D, Dubois C (2009) Cancer cell-derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo. J Exp Med 206(9):1913–1927

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Author notes

    Authors and Affiliations

    1. INSERM UMR-S1076, VRCM, Aix Marseille Université, 27 Boulevard Jean Moulin, 13385, Marseille, France

      Diane Mege, Françoise Dignat-George, Christophe Dubois & Laurence Panicot-Dubois

    2. Service de Chirurgie Digestive, CHU La Timone, 264 rue Saint Pierre, 13385, Marseille, France

      Diane Mege

    3. Service de Médecine Nucléaire, CHU La Timone, Faculté de Médecine de Marseille, Aix Marseille Université, 27, Boulevard Jean Moulin, 13005, Marseille, France

      Serge Cammilleri & Olivier Mundler

    4. Laboratoire d’Hématologie, CHU Conception, 385 Bld Baille, 13385, Marseille, France

      Françoise Dignat-George

    5. Rheumatology Department 1, CHU Sainte Marguerite, 270, boulevard de Sainte Marguerite AP-HM, 13009, Marseille, France

      Sandrine Guis

    6. CRMBM-CEMEREM UMR 7339, MSK Group, Faculté de Médecine de la Timone, Aix-Marseille Université, 27 Boulevard Jean Moulin, 13385, Marseille, France

      Sandrine Guis

    Authors
    1. Diane Mege
      View author publications

      You can also search for this author in PubMed Google Scholar

    2. Serge Cammilleri
      View author publications

      You can also search for this author in PubMed Google Scholar

    3. Olivier Mundler
      View author publications

      You can also search for this author in PubMed Google Scholar

    4. Françoise Dignat-George
      View author publications

      You can also search for this author in PubMed Google Scholar

    5. Christophe Dubois
      View author publications

      You can also search for this author in PubMed Google Scholar

    6. Laurence Panicot-Dubois
      View author publications

      You can also search for this author in PubMed Google Scholar

    7. Sandrine Guis
      View author publications

      You can also search for this author in PubMed Google Scholar

    Corresponding author

    Correspondence to Sandrine Guis.

    Ethics declarations

    Conflict of interest

    All authors declare that they have no conflict of interest.

    Ethical approval

    All procedures performed in this study involving human were in accordance with the ethical standards of the institutional and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

    Informed consent

    Informed consent was obtained from all individual participants included in the study.

    Additional information

    Diane Mege and Serge Cammilleri have contributed equally to this work.

    Rights and permissions

    Reprints and permissions

    About this article

    Check for updates. Verify currency and authenticity via CrossMark

    Cite this article

    Mege, D., Cammilleri, S., Mundler, O. et al. Circulating microparticles bearing Fibrin associated with whole-body 18FDG-PET: diagnostic tools to detect paraneoplastic polymyalgia rheumatica. Rheumatol Int 36, 1099–1103 (2016). https://doi.org/10.1007/s00296-016-3510-7

    Download citation

    • Received:

    • Accepted:

    • Published:

    • Issue Date:

    • DOI: https://doi.org/10.1007/s00296-016-3510-7

    Keywords

    Search

    Navigation