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Undifferentiated spondyloarthritis in a heterogeneous Brazilian population: an eight-year follow-up study

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Abstract

The aim of the present study was to describe the outcomes of Brazilian patients with undifferentiated spondyloarthritis during an eight-year follow-up period. Patients fulfilling the European Spondyloarthritis (SpA) Study Group Classification Criteria were enrolled. Forty patients were seen at baseline, and 36 participated in the follow-up study. Twenty-three (58 %) were female, and there were 24 (60 %) African Brazilians enrolled. HLA-B27 was positive in 18 (45 %) patients. At disease onset, the first presenting symptoms were pure peripheral manifestations in 26 (72.2 %) patients. After the study period, mixed disease (axial + peripheral) predominated occurring in 25 (69.4 %) patients. The Assessment of SpA International society (ASAS) classification criteria for axial SpA were fulfilled by 77 % of patients, and the ASAS criteria for peripheral SpA were fulfilled by 59 % of patients. After 2.5 years, 6 (16.7 %) of the 36 patients fulfilled the modified New York Criteria for ankylosing spondylitis and 1 (2.7 %) progressed to psoriatic arthritis. A total of 10 (27.8 %) patients progressed to definite SpA during the eight-year study period. Buttock pain (p = 0.006, OR 10.55; 95 % CI 2.00–65.90) and low-grade radiographic sacroiliitis (p = 0.025, OR = 11.50; 95 % CI 1.33–83.39) at baseline were associated with definite SpA. Thus, in this Brazilian cohort, which had a predominance of female African-Brazilian patients, prevalent peripheral onset symptoms were followed by a high frequency of axial manifestations during the follow-up period. Evidence of clinical or radiological sacroiliitis was associated with progression to definite SpA.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Unit of Rheumatology, Department of Locomotor System, Federal University of Minas Gerais, Av. Brasil, 248/sala 705, Belo Horizonte, MG, 30140-001, Brazil

    Ricardo da Cruz Lage, Carlos Alexandre de Souza Bomtempo, Adriana Maria Kakehasi & Marco Antônio Parreiras de Carvalho

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  1. Ricardo da Cruz Lage
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  2. Carlos Alexandre de Souza Bomtempo
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  3. Adriana Maria Kakehasi
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  4. Marco Antônio Parreiras de Carvalho
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Correspondence to Ricardo da Cruz Lage.

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da Cruz Lage, R., de Souza Bomtempo, C.A., Kakehasi, A.M. et al. Undifferentiated spondyloarthritis in a heterogeneous Brazilian population: an eight-year follow-up study. Rheumatol Int 34, 1019–1023 (2014). https://doi.org/10.1007/s00296-013-2797-x

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