Lebersinusoide: Pathologie endothelialer Befunde

Liver sinusoids: pathology of endothelial findings

Zusammenfassung

Das klinische Bild sinusoidaler Erkrankungen der Leber ist eher uncharakteristisch. Es äußert sich in einem breiten klinischen Manifestationsspektrum wie Hepatomegalie, portaler Hypertonus oder als chronisches Leberversagen unbekannter Ursache. Im Gegensatz zu anderen Lebererkrankungen fehlt es an spezifischen serologischen, immunserologischen und röntgenologischen Befunden. Häufig weisen erst bioptische Befunde auf eine sinusoidale Erkrankung hin. Diese Übersicht möchte einen praktisch orientierten Überblick über Leberumbauprozesse, hämodynamische Störungen und vaskuläre Tumoren geben.

Abstract

This review covers a spectrum of pathologic changes and diseases involving hepatic sinusoids. In the majority of patients, clinical findings are rather uncharacteristic such as hepatomegaly, portal hypertension, or lingering liver failure of unknown origin. In contrast to more common hepatic disorders, characteristic clinical, serological, immunoserological, and radiographical findings are lacking. In these cases, biopsy findings may be crucial to guide treatment decisions. This review covers a variety of hepatic disorders that practicing pathologists may encounter in their clinical routine.

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Correspondence to PD Dr. Diane Goltz.

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D. Goltz und H.-P. Fischer geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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H. Baba, Essen

T. Longerich, Heidelberg

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Goltz, D., Fischer, H. Lebersinusoide: Pathologie endothelialer Befunde. Pathologe (2020). https://doi.org/10.1007/s00292-020-00802-y

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Schlüsselwörter

  • Hepatisches Sinus-Obstruktionssyndrom
  • Peliosis hepatis
  • Hepatische endotheliale Neoplasien
  • Hepatomegalie
  • Leberumbauprozesse

Keywords

  • Hepatic sinusoidal obstruction syndrome
  • Peliosis hepatis
  • Hepatic endothelial neoplasias
  • Hepatomegaly
  • Hepatic vascular remodeling