Zusammenfassung
Der Zugang zu gut charakterisierten menschlichen Bioproben ist eine der wichtigsten Voraussetzungen für die moderne biomedizinische Forschung. Biobanken spielen hier eine entscheidende Rolle, da sie entsprechende Bioproben für geplante Analysen zur Verfügung stellen. Hierfür müssen viele Störfaktoren, die die Qualität von Bioproben beeinflussen, beachtet werden. Neben logistischen, ethischen und datenschutzrechtlichen Aspekten sind hier v. a. präanalytische Variablen im Rahmen der Probengewinnung, Verarbeitung und Lagerung zu nennen. Im vorliegenden Paper werden daher die wichtigsten präanalytischen Einflussfaktoren systematisch dargestellt. Außerdem geben wir einen Überblick über aktuelle nationale und internationale Aktivitäten zur standardisierten Erfassung der präanalytischen Variablen, um deren Einfluss auf das Analyseergebnis besser zu verstehen und in Zukunft zu minimieren.
Abstract
Access to well-characterized human biosamples is one of the most important prerequisites for modern biomedical research. Biobanks play a decisive role here, as they provide corresponding biosamples for planned analyses. Many interfering factors influencing the quality of biosamples have to be taken into account. In addition to logistical, ethical, and data protection aspects, preanalytical variables in the context of sample acquisition, storage, and processing should be mentioned in particular. In this paper, therefore, the most important preanalytical influencing factors are presented systematically and an overview of current national and international activities for the standardized recording of these factors is provided with the goal of being able to better understand their influence on results and to minimize them in the near future.
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K.-F. Becker, J. Wipperfürth und E. Herpel geben an, dass kein Interessenkonflikt besteht.
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E. Dahl, Aachen
P. Schirmacher, Heidelberg
R. Knüchel-Clarke, Aachen
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Becker, KF., Wipperfürth, J. & Herpel, E. Präanalytik und Biobanking. Pathologe 39, 297–302 (2018). https://doi.org/10.1007/s00292-018-0437-7
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DOI: https://doi.org/10.1007/s00292-018-0437-7