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Intraokulare Metastasen

Intraocular metastases

  • Schwerpunkt: Tumoren der Sinnesorgane
  • Published:
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Zusammenfassung

Metastasen sind die häufigsten intraokularen Malignome. Aufgrund seiner ausgeprägten Gefäßversorgung ist die Aderhaut die häufigste Lokalisation intraokularer Metastasen (ca. 90 %). Weniger als 10 % der intraokularen Metastase befinden sich in der Iris und/oder dem Ziliarkörper, während die Netzhaut und der Glaskörper seltener betroffen sind. Die meisten intraokularen Metastasen sind Karzinome; bei Frauen ist das Mammakarzinom der häufigste Primärtumor, bei Männern das Lungenkarzinom. In der Literatur sind aber intraokulare Metastasen von praktisch allen menschlichen Malignomen beschrieben. In diesem Übersichtsartikel werden neben der Pathologie intraokularer Metastasen deren klinisches Erscheinungsbild, nicht-invasive und invasive diagnostische Prozeduren sowie die pathologische Aufarbeitung von zytologischen und histologischen Proben, die durch Feinnadelaspirationsbiopsie oder mittels spezieller Biopsiepinzette gewonnen werden, beschrieben.

Abstract

Metastatic cancer represents the most common form of intraocular malignancy. Due to its abundant vascular supply the choroid is the most common ocular site for intraocular metastatic disease (approximately 90%). Less than 10% of intraocular metastases are located in the iris and/or ciliary body, whereas the retina and vitreous are rarely affected. Most intraocular metastases are carcinomas; the majority of metastases originate from breast cancer in females and lung cancer in males. However, virtually every primary malignancy has been described to metastasize to intraocular structures. In this review we address the pathology and clinical features of intraocular metastases, noninvasive and invasive diagnostic procedures, as well as the pathological work-up of cytological and histological specimens obtained either by fine needle aspiration biopsy or special biopsy forceps.

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Danksagung

Die Autoren bedanken sich bei Frau Ricarda Ulankiewicz und Frau Corinna Lux für ihre Unterstützung bei der Darstellung der Aufarbeitung des intraokularen Probenmaterials.

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Authors and Affiliations

  1. Institut für Pathologie, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Deutschland

    D. Westerwick, F. Driever, K. W. Schmid &  K. A. Metz

  2. Klinik für Augenheilkunde, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Deutschland

    C. H. D. Le Guin

  3. Westdeutsches Tumorzentrum (WTZ), Universitätsklinikum Essen, Essen, Deutschland

    K. W. Schmid

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  1. D. Westerwick
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  2. F. Driever
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  3. C. H. D. Le Guin
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  4. K. W. Schmid
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  5. K. A. Metz
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Corresponding author

Correspondence to K. A. Metz.

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Interessenkonflikt

D. Westerwick, F. Driever, C. H. D. Le Guin, K. W. Schmid und K. A. Metz geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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F. Fend, Tübingen

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Westerwick, D., Driever, F., Le Guin, C.H.D. et al. Intraokulare Metastasen. Pathologe 38, 500–506 (2017). https://doi.org/10.1007/s00292-017-0373-y

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  • DOI: https://doi.org/10.1007/s00292-017-0373-y

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