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Zelluläre Seneszenz im kolorektalen Karzinom

Cellular senescence and colorectal cancer

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Zusammenfassung

Zelluläre Seneszenz ist neben Proliferation und Zelltod eine wichtige Reaktion auf stressassoziierte Stimuli. Ursprünglich als In-vitro-Phänomen beschrieben, ist sie an vielen physiologischen und pathophysiologischen Prozessen beteiligt. Im Rahmen der Entstehung solider und generalisierter Tumorerkrankungen stellt Seneszenzinduktion beispielsweise eine wichtige Barriere gegen die Progression der Krankheit dar. Dies konnte für maligne Lymphome, Melanome und verschiedene Karzinome im Tiermodell demonstriert werden. Doch seneszente Zellen bleiben hochgradig sekretorisch aktiv und haben einen wichtigen Effekt auf ihre Nachbarzellen sowie den gesamten Gewebeverband. Im vorliegenden Artikel soll ein Einblick in die aktuelle Studienlage gegeben und es sollen klinische Implikationen und zukünftige Anwendungsmöglichkeiten diskutiert werden.

Abstract

Apart from proliferation and cell death, cellular senescence is an important response to numerous stress-associated stimuli. Originally described as an in vitro phenomenon, it is involved in various physiological and pathophysiological processes. For example, during the development of solid and generalized tumors, senescence induction poses an important barrier against disease progression. This could be demonstrated for malignant lymphomas, melanomas and various carcinomas using sophisticated animal models. However, senescent cells remain highly secretorically active and have a profound effect on neighboring cells as well as the entire tissue network. This article tries to provide insight into the current literature and discusses clinical implications and future applications.

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Förderung

S. Foersch wird in seiner Arbeit durch das Stufe-1-Programm der Universitätsmedizin Mainz, durch die Manfred-Stolte-Stiftung und durch das UCT TransMed Fellowship unterstützt.

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  1. Institut für Pathologie, Universitätsmedizin Mainz, Langenbeckstr. 1, Gebäude 706, 55131, Mainz, Deutschland

    S. Foersch

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S. Foersch gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine vom Autor durchgeführten Studien an Menschen oder Tieren, welche noch nicht publiziert wurden. Hinsichtlich der Einhaltung ethischer Richtlinien beachten Sie die jeweiligen Originalarbeiten.

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Foersch, S. Zelluläre Seneszenz im kolorektalen Karzinom. Pathologe 38 (Suppl 2), 205–210 (2017). https://doi.org/10.1007/s00292-017-0357-y

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