Skip to main content
SpringerLink
Log in

Lymphozytäre Ösophagitis

Eine Ausschlussdiagnose in der Diagnostik chronischer Ösophagitiden

Lymphocytic esophagitis

An entity to be excluded in chronic inflammatory diseases of the esophagus

  • Schwerpunkt
  • Published:
Der Pathologe Aims and scope Submit manuscript

Zusammenfassung

Die lymphozytäre Ösophagitis stellt eine seltene, nicht eindeutig definierte, chronisch-entzündliche Erkrankung der Speiseröhre dar, die durch eine erhöhte Anzahl intraepithelialer Lymphozyten charakterisiert ist. Bis jetzt konnten weder klinische Symptome noch endoskopische Befunde eindeutigen histologischen Kriterien zugeordnet werden. So bleibt die Erkrankung derzeit noch eine Ausschlussdiagnose nach Exklusion aller anderen potenziellen Ursachen einer ösophagealen intraepithelialen Lymphozytose.

Abstract

Lymphocytic esophagitis is a rare, ill-defined inflammatory disease of the esophagus and is characterized by an increased number of intraepithelial lymphocytes. Up to now no distinct clinical symptom or endoscopic finding could be linked to histopathological changes. Hence lymphocytic esophagitis remains a diagnosis by exclusion after ruling out other possible causes of esophageal intraepithelial lymphocytosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1

Literatur

  1. Rubio CA, Krister S, Lagergren J (2006) Lymphocytic esophagitis: a histologic subset of chronic esophagitis. Am J Clin Pathol 125:432–437

    PubMed  Google Scholar 

  2. Mangano MM, Antonioli DA, Schnitt SJ (1992) Nature and significance of cells with irregular nuclear contours in esophageal mucosal biopsies. Mod Pathol 5:191–196

    PubMed  CAS  Google Scholar 

  3. Esposito S, Valente G, Zvallone A et al (2004) Histological score for cells with irregular nuclear contours for the diagnosis of reflux esophagitis in children. Hum Pathol 35:96–101

    Article  PubMed  Google Scholar 

  4. Purdy JK, Appelman HD, Golembeski CP et al (2008) Lymphocytic esophagitis: a chronic or recurring pattern of esophagitis resembling allergic contact dermatitis. Am J Clin Pathol 130:508–513

    Article  PubMed  Google Scholar 

  5. Ebach DR, Vanderheyden AD, Ellison JM et al (2011) Lymphocytic esophagitis: a possible manifestation of pediatric upper gastrointestinal Crohn’s disease. Inflamm Bowel Dis 17:45–49

    Article  PubMed  Google Scholar 

  6. Haque S, Genta RM (2012) Lymphocytic oesophagitis: clinicopathological aspects of an emerging condition. Gut 61:1108–1114

    Article  PubMed  Google Scholar 

  7. Cohen S, Saxena A, Waljee AK et al (2012) Lymphocytic esophagitis: a diagnosis of increasing frequency. J Clin Gastroenterol 46:828–832

    Article  PubMed  Google Scholar 

  8. Kasirye Y, John A, Rall C et al (2012) Lymphocytic esophagitis presenting as chronic dysphagia. Clin Med Res 10:83–84

    Article  PubMed  Google Scholar 

  9. Ronkainen J, Walker MM, Aro P et al (2012) Lymphocytic oesophagitis, a condition in search of a disease? Gut 61:1776

    Article  PubMed  Google Scholar 

  10. Ronkainen J, Aro P, Storskrubb T et al (2005) High prevalence of gastroesophageal reflux symptoms and esophagitis with or without symptoms in the general adult Swedish population: a Kalixanda study report. Scand J Gastroenterol 40:275–285

    Article  PubMed  Google Scholar 

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

  1. Institut für Pathologie, Klinikum Bayreuth, Preuschwitzerstr. 101, 95445, Bayreuth, Deutschland

    L. Veits & J. Drgac

  2. Institut für Pathologie, Universitätsklinikum Erlangen, Erlangen, Deutschland

    R.J. Rieker

Authors
  1. L. Veits
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Drgac
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R.J. Rieker
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to L. Veits.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Veits, L., Drgac, J. & Rieker, R. Lymphozytäre Ösophagitis. Pathologe 34, 105–109 (2013). https://doi.org/10.1007/s00292-012-1726-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00292-012-1726-1

Schlüsselwörter

Keywords

Search

Navigation