Graft copolymer of PVP—A sutureless, haemostatic bioadhesive for wound healing application

Abstract

This study includes the application of graft copolymer (polyacrylamide-grafted polyvinyl pyrrolidone—PVP-g-PAM) as wound healing agent. It is hypothesized that the branches of the graft copolymer adsorb at various colloidal components of blood plasma—thus assisting in formation of a networked structure, i.e. ‘blood clot’. Further, the adhesive property of graft copolymer supports in wound closure and immobilization of pathogens. Wound healing efficiency of PVP-g-PAM has been investigated ‘in vivo’ by excision and incision wound model. The 100% wound contraction has been shown by PVP-g-PAM after 13 days. This is superior to both in cases of standard drug and ungrafted polyvinyl pyrrolidone (PVP), which fails to achieve complete wound closure even after 21 days. Additionally, the graft copolymer-treated mice’s skin exhibited higher tensile strength than that of standard drug, PVP and stitched model.

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Acknowledgement

The authors are grateful to Prof. S. Samanta, Head of the department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India. This study has been carried out under his kind guidance. We are also thankful to CIF-BIT Mesra for its kind assistance.

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Correspondence to Pinki Pal or Gautam Sen.

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Pal, P., Rangra, N., Samanta, S. et al. Graft copolymer of PVP—A sutureless, haemostatic bioadhesive for wound healing application. Polym. Bull. 77, 5191–5212 (2020). https://doi.org/10.1007/s00289-019-03013-5

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Keywords

  • Graft copolymer
  • Wound healing
  • Excision model
  • Incision model
  • Tensile strength