Photo-responsive polymeric micelles bearing ammonium salts cross-linked for efficient drug delivery
- 109 Downloads
The cationic photo-responsive polymeric micelles (mPEG-b-p(DEMA-co-MMA-CL)) with light-switchable cross-linker were designed and fabricated by atom transfer radical polymerization and quaternization. These micelles were well dispersed spherical with positive charge. The efficient release of encapsulated contents can be triggered by light irradiation. No significant toxicity was observed of copolymer and its photolysis residues at concentrations up to 250 μg/mL. The antitumor activity of camptothecin (CPT) in micelles demonstrated that light triggered the release of CPT, which dramatically improves the cytotoxicity after UV irradiation.
KeywordsPhoto-responsive Polymeric micelles Drug delivery Cationic
This work was financially supported by Natural Science Basic Research Project of Shaanxi Provincial Department of Science and Technology (2018JQ8041), the Association of Young Supporting Project of Shaanxi (20170410), the Provincial Key Discipline Construction Project of Pharmacy of Xi’an Medical University (2016YXXK03), the National Natural Science Foundation of China (81302706), Natural Science Basic Research Program of Shaanxi (2017JM8124) and the Shaanxi Provincial Education Department Project (17JK0663).
- 24.Lili Y et al (2016) Photo/pH dual-responsive biocompatible poly(methacrylic acid)-based particles for triggered drug delivery. J Appl Polym Sci 133:44003Google Scholar