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Polymer Bulletin

, Volume 76, Issue 5, pp 2233–2252 | Cite as

Preparation and characterization of nanocomposites based on different zeolite frameworks as carriers for anticancer drug: zeolite Y versus ZSM-5

  • M. Karimi
  • M. Habibizadeh
  • K. RostamizadehEmail author
  • M. Khatamian
  • B. Divband
Original Paper
  • 68 Downloads

Abstract

This research was to investigate and characterize different types of zeolites, i.e., Y and ZSM-5 as well as their corresponding nanocomposite of PEG (PEG/Y and PEG/ZSM-5), as carrier for loading and release of curcumin. Zeolites and PEG/zeolite nanocomposites were characterized by XRD, SEM and FT-IR techniques. Curcumin encapsulation efficiency of zeolite Y, ZSM-5, PEG/Y and PEG/ZSM-5 was determined to be 61.06, 40.45, 45.59 and 37.76%, respectively. Nitrogen adsorption–desorption measurement was used to measure the surface area and the pore volume of the hosts before and after curcumin loading. The decrease in surface areas and pore volumes after drug loading was attributed to the inclusion of curcumin in the zeolites pores. In vitro drug release of curcumin was studied in buffer solution (pH = 5.4 and 7.4) at 37 °C. The results showed higher levels of curcumin release from zeolite Y compared to ZSM-5. The zeolite nanocomposites also revealed the higher level of released curcumin in comparison with the corresponding zeolites. The amount of curcumin released at pH = 5.4 was higher than at pH = 7.4, which can be used as evidence to demonstrate the pH sensitivity of the zeolite as drug carrier. From the results, it can be concluded that zeolite-based drug delivery systems can be considered as promising candidate for delivery of hydrophobic drugs such as curcumin.

Keywords

Zeolite Y ZSM-5 zeolite Nanocomposite Drug delivery 

Notes

Acknowledgements

We are most grateful for the continuing financial support of this research project by Zanjan University of Medical Sciences and University of Tabriz.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Inorganic Chemistry, Faculty of ChemistryUniversity of TabrizTabrizIran
  2. 2.Department of Pharmaceutical Biomaterials, School of PharmacyZanjan University of Medical SciencesZanjanIran
  3. 3.Student Research CommitteeZanjan University of Medical SciencesZanjanIran
  4. 4.Zanjan Pharmaceutical Nanotechnology Research Center, School of PharmacyZanjan University of Medical SciencesZanjanIran
  5. 5.Dental and Periodontal Research CenterTabriz University of Medical SciencesTabrizIran
  6. 6.Infectious and Tropical Diseases Research CenterTabriz University of Medical SciencesTabrizIran

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