Thermo/pH/magnetic-triple sensitive poly(N-isopropylacrylamide-co-2-dimethylaminoethyl) methacrylate)/sodium alginate modified magnetic graphene oxide nanogel for anticancer drug delivery
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Herein, thermo/pH/magnetic-triple sensitive nanogel comprised of poly(N-isopropylacrylamide), poly(2-dimethylaminoethyl) methacrylate), sodium alginate, and magnetic graphene oxide were synthesized using N,N-methylenebisacrylamide as a crosslinking agent, sodium dodecylsulfate as a surfactant, and ammonium persulfate as an initiator. The size, chemical structure, thermal stability, and morphology of the prepared nanogel were characterized using different methods. Transmittance of the obtained nanogel was investigated at varying pH and temperature in the presence and absence of magnet. The drug loading ability of synthesized nanogel was examined at different times and concentrations of doxorubicin. Additionally, the release rate of doxorubicin as an anticancer drug from the loaded nanogel was studied at different pH and temperature in the presence and absence of magnet. The biological performance of the formed nanogel was evaluated by seeding it onto MCF-7 cells at different times and concentrations. It was found that this triple responsible nanogel might provide a perfect basis for controlled drug delivery systems.
KeywordsNanogel Magnetic graphene oxide Anticancer drug
The authors wish to thank Payame Noor University and National Elites Foundation for their financial support of this study.
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