Synthesis and characterization of antipyrine-imprinted polymers and their application for sustained release
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In view of technological significance of molecularly imprinted polymers (MIPs) in drug delivery, the ‘grafting from’ approach was employed to develop surface-imprinted silica particles for selective recognition and sustained delivery of a pharmaceutical drug antipyrine (ANP). ANP–MIP was fabricated using methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker by UV irradiation via iniferter approach. Voltammetric measurements was used to scale the extraction and rebinding of ANP on glassy carbon electrode with Pt wire as counter electrode, Ag/AgCl as reference electrode. Various parameters were optimized for ascertaining the performance of ANP–MIP such as time, temperature, and pH. Grafted MIP was characterized by FTIR, thermogravimetry, elemental analysis, surface morphology (AFM) besides the recognition, rebinding and selectivity studies. Calibration curve linearly increases in concentration range of 0.1–2.0 mM with correlation coefficient R2 = 0.976 and limit of detection (LOD) as 0.448 µg mL−1. Thus, fabricated ANP–MIP was studied for controlled release of drug under varying conditions.
KeywordsMolecular imprinting Surface-imprinted polymer Iniferter Antipyrine Controlled release
Authors acknowledge Department of Chemistry, Banaras Hindu University for AFM analysis. AK acknowledges UGC and BHU for university research fellowship. Financial assistance from DST, New Delhi is acknowledged (Grant no. EMR/2016/005245).
- 1.Brodie BB, Axelrod J (1950) The fate of antipyrine in man. J Pharmacol Exp Ther 98:97–104Google Scholar
- 8.Sakamoto JH, van de Ven AL, Godin B, Blanco E, Serda RE, Grattoni A, Ziemys A, Bouamrani A, Hu T, Ranganathan SI, De Rosa E, Martinez JO, Smid CA, Buchanan RM, Lee S-Y, Srinivasan S, Landry M, Meyn A, Tasciotti E, Liu X, Decuzzia P, Ferrari M (2010) Enabling individualized therapy through nanotechnology. Pharmacol Res 62:57–89CrossRefGoogle Scholar
- 19.Gazzaniga A, Sangalli M, Giordano F (1994) Oral Chronotopic® drug delivery systems: achievement of time and/or site specificity. Eur J Pharm Biopharm 40:246–250Google Scholar
- 21.Gazzaniga A, Busetti C, Sangalli ME, Moro L, Giordano F (1995) Oral delayed-release system for colonic specific delivery. Int J Pharm 5:83–88Google Scholar
- 22.Yang G, Wang D, Li Z, Zhou S, Chen Y (2003) Adsorption isotherms on aminoantipyrine imprinted polymer stationary phase. Chromatographia 58(1):53–58Google Scholar
- 26.Skoog DA, Holler FT, Nieman TA (1998) Principles of instrumental analysis, 5th edn. Harcourt Brace College Publishers, Florida, pp 13–14Google Scholar
- 27.Frisch MJ, Trucks GW, Schlegel HB, Scuseria GE., Robb MA, Cheeseman JR, Montgomery JA, Vreven JT, Kudin KN, Burant JC, Millam JM, Iyengar SS, Tomasi J, Barone V, Mennucci B, Cossi M, Scalmani G, Rega N, Petersson GA, Nakatsuji H, Hada M, Ehara M, Toyota K, Fukuda R, Hasegawa J, Ishida M, Nakajima T, Honda Y, Kitao O, Nakai H, Klene M, Li X, Knox JE, Hratchian HP, Cross JB, Bakken V, Adamo C, Jaramillo J, Gomperts R, Stratmann RE, Yazyev O, Austin AJ, Cammi R, Pomelli C, Ochterski JW, Ayala PY, Morokuma K, Voth GA, Salvador P, Dannenberg JJ, Zakrzewski VG, Dapprich S, Daniels AD, Strain MC, Farkas O, Malick DK, Rabuck AD, Raghavachari K, Foresman JB, Ortiz JV, Cui Q, Baboul AG, Clifford S, Cioslowski J, Stefanov BB, Liu G, Liashenko A, Piskorz P, Komaromi I, Martin RL, Fox DJ, Keith T, Al-Laham MA, Peng CY, Nanayakkara A, Challacombe M, Gill PMW, Johnson B, Chen W, Wong MW, Gonzalez C, Pople JA (2004) Gaussian03 Revision D01. Gaussian Inc, Walling fordGoogle Scholar
- 28.Dennington R, Keith T, Millam J (2007) GaussView 4.1. Semichem, Inc. Shawnee MissionGoogle Scholar
- 36.Cunliffe D, Kirby A, Alexander C (2005) Molecularly imprinted drug delivery systems. Adv Drug Deliv Rev 57:1836–1853Google Scholar
- 38.Zaidi SA (2016) Molecular imprinted polymers as drug delivery vehicles. Drug Deliv 23:2262–2271Google Scholar