Properties of PLDLA/bioglass scaffolds produced by selective laser sintering
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This paper reports an evaluation of the structure, the flexural and viscoelastic properties, and the cytotoxicity of scaffolds produced from PLDLA and bioglass (BG) by selective laser sintering. The process conditions used in the scaffold preparation resulted in microstructures with a high sintering degree. The range of porosity values obtained for the scaffolds was 26–30%, which is appropriate for scaffold applications, and the average pore size in the PLDLA/BG scaffolds was 200 μm. The flexural modulus, ultimate strength, and elongation values for the PLDLA/BG scaffold specimens decreased for scaffolds with 20 and 30% of BG, probably due to the low chemical affinity between the polymeric and the ceramic phase. The PLDLA/BG scaffolds exhibited flexural modulus values between 10 and 79 MPa, depending on the scaffold composition, which lie within the range reported for human bone. In the direct cytotoxicity tests, cells seeded on PLDLA/BG scaffolds showed a high viability, indicating that the PLDLA/BG scaffolds prepared by selective laser sintering can be applied in bone repair.
KeywordsPLDLA/bioglass Scaffold properties Selective laser sintering
The authors would like to thank PRONEX-FAPESC, CNPq, and CAPES for financial support and also LCME-UFSC for the SEM micrographs.
- 4.Das S, Hollister SJ (2003) Tissue engineering scaffolds. In: Buschow KHJ, Cahn RW, Flemings MC, Ilschner B, Kramer EJ, Mahajan S (eds) Encyclopedia of materials: science and technology. Elsevier, AmsterdamGoogle Scholar
- 10.Salmoria GV, Hotza D, Klauss P, Kanis LA, Roesler CRM (2014) Manufacturing of porous polycaprolactone prepared with different particle sizes and infrared laser sintering conditions: microstructure and mechanical properties. Adv Mech Eng 2014:art. no. 640496. doi: 10.1155/2014/640496 CrossRefGoogle Scholar
- 14.Chen Q, Roether JA, Boccaccini AR (2008) Tissue engineering scaffolds from bioactive glass and composite materials. In: Ashammakhi N, Reis R, Cjielini F (eds) Topics in tissue engineering. TBE Group, Illinois (e-book) Google Scholar
- 17.ISO document 10993-5, 1992 Biological evaluation of medical devices: part 5. Tests for cytotoxicity: in vitro methodsGoogle Scholar