Polymer Bulletin

, Volume 75, Issue 3, pp 1329–1348 | Cite as

Cellulose acetate butyrate bilayer coated microspheres for controlled release of ciprofloxacin

  • Keerti V. Phadke
  • Lata S. Manjeshwar
  • Tejraj M. Aminabhavi
  • M. P. Sathisha
Original Paper


Novel non-toxic cellulose acetate butyrate (CAB) bilayer coated microspheres of gelatin (GE) prepared without using a cross-linker were used for investigating the controlled release of ciprofloxacin (CFX). The microspheres were characterized by Fourier transform infrared spectroscopy to understand CAB coating and its chemical inertness towards CFX. Differential scanning calorimetry was used to investigate the molecular level drug dispersion into the polymer matrix, while scanning electron microscopy was used to investigate the surface morphology of the formulated microspheres. Mean particle sizes ranged between 240 and 847 μm, while equilibrium water uptake performed in double distilled water ranged between 492 and 3152%. The drug loaded formulations exhibited high encapsulation efficiency up to 91%. The in vitro release studies performed in acidic and alkaline media indicated influence of GE and CFX content as well as amount of CAB coating on the release characteristics of CFX that was extended up to 20 h. Analysis of in vitro results using empirical equations suggested a non-Fickian release mechanism.


Thermosensitive Gelatin Ciprofloxacin Controlled release Cellulose acetate butyrate Bilayer coating 

Supplementary material

289_2017_2092_MOESM1_ESM.xlsx (104 kb)
Supplementary material 1 (XLSX 105 kb)


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Keerti V. Phadke
    • 1
  • Lata S. Manjeshwar
    • 1
  • Tejraj M. Aminabhavi
    • 2
  • M. P. Sathisha
    • 3
  1. 1.Department of ChemistryKarnatak UniversityDharwadIndia
  2. 2.SET’s College of PharmacyDharwadIndia
  3. 3.PG Department of ChemistryKLE’s P.C. Jabin Science CollegeHubliIndia

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