Preparation and characterization of electrospun polyacrylonitrile fiber mats containing Garcinia mangostana
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Garcinia mangostana-loaded electrospun polyacrylonitrile (PAN) fiber mats with antibacterial and anti-tuberculosis properties were fabricated from PAN solution containing G. mangostana extract in dimethylformamide. 10% PAN solution was mixed with G. mangostana in amounts of 10, 15, 20, and 30 wt% based on the weight of PAN powder used in the experiment. The PAN solutions were processed using the electrospinning process. Both untreated (neat) and G. mangostana-loaded PAN fibers were smooth in appearance, and the average diameter of samples was ~215 and ~245 nm, respectively. Morphologies, release characteristics, antimicrobial efficiencies against Staphylococcus aureus, Methicillin-resistant S. aureus (MRSA), Staphylococcus epidermidis, Streptococcus agalactiae, Streptococcus pyogenes, and anti-tuberculosis properties of the neat electrospun and 10–30% G. mangostana-loaded e-spun fiber mats were investigated. In vitro release studies of G. mangostana from e-spun PAN fiber mats were determined using the total immersion method in acetate buffer and phosphate buffer solutions containing Tween 80 and methanol. The cumulative released amount of G. mangostana from the samples proportionally increased with the increase of G. mangostana incorporated in the spinning solutions. This study demonstrated a convenient procedure with the potential to develop the antimicrobial and anti-tuberculosis properties of electrospun fibrous membranes containing G. mangostana, which are beneficial in filtration applications for respirators, face masks, and air-conditioning filters.
KeywordsElectrospinning Polyacrylonitrile Garcinia mangostana
The authors acknowledge financial support received from the Research Pyramid, Rachadaphiseksomphot Endowment Fund (GCURP_58_02_63_01) of Chulalongkorn University. This work was supported in part by (1) the Petroleum and Petrochemical College, Chulalongkorn University, (2) the Center of Excellence for Petroleum, Petrochemicals, and Advanced Materials (CE-PPAM), (3) the Center of Excellent for Innovation in Chemistry (PERCH-CIC), Commission on Higher Education, (4) Department for Development of Thai Traditional and Alternative Medicine Ministry of Health, Ministry of Public Health of Thailand, and (5) the Faculty of Biotechnology, Ramkhamhaeng University.
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