Current Microbiology

, Volume 75, Issue 7, pp 787–793 | Cite as

Correlation Between Quorum Sensing Signal Molecules and Pseudomonas aeruginosa’s Biofilm Development and Virulency

  • Abayomi Babatunde Alayande
  • Mar Mar Aung
  • In S. Kim


Bacteria, when adhered to a substratum, can form biofilms. Nevertheless, many factors dictate biofilm formation and virulence factor production, including a response by the bacteria to their surroundings. This system is referred to as Quorum sensing (QS) also known as cell–cell communication. Pseudomonas aeruginosa is an infection causing agent in immune-compromised patients, it uses acyl-homoserine lactone (AHL) to coordinate its QS systems. In this work, the connection between some members of AHL produced by P. aeruginosa PAO1 and its biofilm development and the production of virulence factor was investigated. It was discovered that N-butanoyl-homoserine lactone (C4-HSL) and N-hexanoyl-l-homoserine lactone (C6-HSL) perform a more consequential and eminent function in the biofilm maturation and virulence factor production while N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL) plays a role in biofilm initiation. Because QS has been reported to be required for biofilm development and pathogenesis of P. aeruginosa, the results of this work have great importance and significance for the design of strategies for the control and prevention of biofilms.



This research was supported by a Grant (code 18IFIP-B087389-05) from the Industrial Facilities and Infrastructure Research Program funded by the Ministry of Land, Infrastructure, and Transport of Korean government.

Compliance with Ethical Standards

Conflict of interest

The authors declare no competing financial interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Abayomi Babatunde Alayande
    • 1
  • Mar Mar Aung
    • 2
  • In S. Kim
    • 1
  1. 1.Global Desalination Research Center (GDRC), School of Earth Sciences and Environmental EngineeringGwangju Institute of Science and Technology (GIST)GwangjuSouth Korea
  2. 2.Department of BiotechnologyMandalay Technological University (MTU)PatheingyiRepublic of the Union of Myanmar

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