Abstract
In recent times, advances in cancer immunotherapy have yielded impressive, durable clinical responses in patients with varied subtypes of cancer. However, a significant proportion of patients who initially demonstrate encouraging tumor regression develop resistance and progress over time. The identification of novel therapeutic approaches to overcome resistance may result in significantly improved clinical outcomes and remains an area of high scientific priority. This review aims to summarize the current knowledge regarding the role of both tumor-intrinsic and tumor-extrinsic factors in the development of resistance to cancer immunotherapy and to discuss current and possible future therapeutic strategies targeting these mechanisms.
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Marco Donia has received honoraria for lectures from Bristol-Myers Squibb, Merck, Astra Zeneca, and Genzyme, as well as financial support for attending symposia from Bristol-Myers Squibb, Merck, Novartis, Pfizer, and Roche. The other authors declare that they have no conflict of interest.
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This article is a contribution to the special issue on Anti-cancer Immunotherapy: Breakthroughs and Future Strategies - Guest Editor: Mads Hald Andersen
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Draghi, A., Chamberlain, C.A., Furness, A. et al. Acquired resistance to cancer immunotherapy. Semin Immunopathol 41, 31–40 (2019). https://doi.org/10.1007/s00281-018-0692-y
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DOI: https://doi.org/10.1007/s00281-018-0692-y