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First-line therapy for advanced non-small cell lung cancer with activating EGFR mutation: is combined EGFR-TKIs and chemotherapy a better choice?

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Abstract

As the standard first-line treatment for advanced non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutation, EGFR-tyrosine kinase inhibitors (EGFR-TKIs) have significantly improved the median progression-free survival (PFS) up to 18.9 months. However, almost all patients eventually develop acquired resistance to EGFR-TKIs, which limits the first-line PFS. To overcome the resistance and improve overall survival, researchers have tried to identify the resistance mechanisms and develop new treatment strategies, among which a combination of EGFR-TKIs and cytotoxic chemotherapy is one of the hotspots. The data from preclinical and clinical studies on combined EGFR-TKIs and chemotherapy have shown very interesting results. Here, we reviewed the available preclinical and clinical studies on first-line EGFR-TKIs–chemotherapy combination in patients with advanced NSCLC harboring activating EGFR mutation, aiming to provide evidences for more potential choices and shed light on clinical treatment.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant no. 81372334) and Shandong Provincial Natural Science Foundation (Grant no. ZR2017PH076).

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  1. Shuyun Wang and Aiqin Gao contributed equally.

Authors and Affiliations

  1. Department of Oncology, Jinan Central Hospital Affiliated to Shandong University, 105 Jiefang Road, Jinan, Shandong, People’s Republic of China

    Shuyun Wang, Aiqin Gao, Jie Liu & Yuping Sun

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  1. Shuyun Wang
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  2. Aiqin Gao
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Correspondence to Yuping Sun.

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Wang, S., Gao, A., Liu, J. et al. First-line therapy for advanced non-small cell lung cancer with activating EGFR mutation: is combined EGFR-TKIs and chemotherapy a better choice?. Cancer Chemother Pharmacol 81, 443–453 (2018). https://doi.org/10.1007/s00280-017-3516-1

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