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Cancer Chemotherapy and Pharmacology

, Volume 79, Issue 3, pp 611–619 | Cite as

Phase I study of pazopanib plus TH-302 in advanced solid tumors

  • Richard F. Riedel
  • Kellen L. Meadows
  • Paula H. Lee
  • Michael A. Morse
  • Hope E. Uronis
  • Gerard C. Blobe
  • Daniel J. George
  • Jeffrey Crawford
  • Donna Niedzwiecki
  • Christel N. Rushing
  • Christy C. Arrowood
  • Herbert I. Hurwitz
Clinical Trial Report

Abstract

Purpose

To define the maximum tolerated dose (MTD), recommended phase II dose (RPTD), and assess safety and tolerability for the combination of pazopanib plus TH-302, an investigational hypoxia-activated prodrug (HAP), in adult patients with advanced solid tumors.

Methods

This was an open-label, non-randomized, single-center, phase I trial consisting 2 stages. Stage 1 was a standard “3 + 3” dose escalation design to determine safety and the RPTD for TH-302 plus pazopanib combination. Stage 2 was an expanded cohort to better describe the tolerability and toxicity profile at the MTD. Pazopanib was orally dosed at 800 mg daily on days 1–28 for all cohorts. TH-302 was administered intravenously on days 1, 8 and 15 of a 28-day cycle at doses of 340 mg/m2 (cohort 1) or 480 mg/m2 (cohort 2). Dose limiting toxicity (DLT) was assessed in the first 28-day cycle. Efficacy was assessed every 2 cycles.

Results

Thirty patients were enrolled between December 2011 and September 2013. In the dose escalation stage, 7 patients were enrolled in the 340 mg/m2 TH-302 cohort and 6 patients in the 480 mg/m2 TH-302 cohort. Ten patients were evaluable for DLT. DLTs included grade 2 intolerable esophagitis (n = 1) in the 340 mg/m2 TH-302 cohort, and grade 3 vaginal inflammation (n = 1) and grade 3 neutropenia with grade 3 thrombocytopenia (n = 1, same patient) in the 480 mg/m2 TH-302 cohort. The 340 mg/m2 TH-302 cohort was determined to be MTD and RPTD. The most common treatment-related adverse events were hematologic (anemia, neutropenia, and thrombocytopenia), nausea/vomiting, palmar-plantar erythrodysesthesia syndrome, constipation, fatigue, mucositis, anorexia, pain, and hypertension. Partial response (PR) was observed in 10% (n = 3) of patients, stable disease (SD) in 57% (n = 17), and progressive disease (PD) in 23% (n = 7). Due to toxicity, 3 patients were discontinued from study drug prior to first radiographic assessment but were included in these calculations. Disease control ≥6 months was observed in 37% of patients (n = 11).

Conclusions

The RPTD for this novel combination is pazopanib 800 mg daily on days 1–28 plus TH-302 340 mg/m2 on days 1, 8 and 15 of each 28-day cycle. Preliminary activity was seen in treatment-refractory cancers and supports potential value of co-targeting tumor angiogenesis and tumor hypoxia.

Keywords

Pazopanib TH-302 Advanced cancer Phase I Hypoxia 

Abbreviations

AE

Adverse event(s)

ATP

Adenosine tri-phosphate

DLT

Dose limiting toxicity

EMT

Epithelial-mesenchymal transition

HAP

Hypoxia-activated prodrug(s)

HGF

Hepatocyte growth factor

IL8

Interleukin 8

IQR

Interquartile range

MTD

Maximum tolerated dose

PD

Progressive disease

PDGFR

Platelet derived growth factor receptor

PR

Partial response

KPS

Karnofsky performance status

RECIST

Response evaluation criteria in solid tumors

RPTD

Recommended phase two dose

SD

Stable disease

SDF1

Stem cell derived factor 1

UTI

Urinary tract infection

VEGF

Vascular endothelial growth factor

VEGFR

Vascular endothelial growth factor receptor

WOCBP

Women of childbearing potential

Notes

Acknowledgements

We gratefully acknowledge the invaluable contributions of the patients and their families. We would also like to acknowledge the Duke University Phase I Oncology clinical trials team.

Compliance with ethical standards

Conflict of interest

Dr. Riedel serves as institutional PI for SARC021: A Trial of TH-302 in Combination with Doxorubicin versus Doxorubicin Alone to Treat Patients with Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma.

Funding source

This study was approved and funded by the National Comprehensive Cancer Network (NCCN) Oncology Research Program from general research support provided by Novartis Pharmaceuticals Corporation (formerly GlaxoSmithKline, LLC) and research supported by Threshold Pharmaceuticals, Inc.

Supplementary material

280_2017_3256_MOESM1_ESM.docx (18 kb)
Supplementary material 1 (DOCX 18 KB)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Richard F. Riedel
    • 1
  • Kellen L. Meadows
    • 1
  • Paula H. Lee
    • 1
  • Michael A. Morse
    • 1
  • Hope E. Uronis
    • 1
  • Gerard C. Blobe
    • 1
  • Daniel J. George
    • 1
  • Jeffrey Crawford
    • 1
  • Donna Niedzwiecki
    • 2
  • Christel N. Rushing
    • 2
  • Christy C. Arrowood
    • 1
  • Herbert I. Hurwitz
    • 1
  1. 1.Duke Cancer InstituteDuke University Medical CenterDurhamUSA
  2. 2.Department of Biostatistics and BioinformaticsDuke University Medical CenterDurhamUSA

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