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Table 1 Clinical characteristics of patients before and after propensity score matching

From: Effect of adjunctive corticosteroid on 28-day mortality in neutropenic patients with septic shock

  Original Propensity-score matched
No-steroid (n = 189) Steroid (n = 98) p value No-steroid (n = 50) Steroid (n = 50) p value
Age, years, mean ± SD 53.5 ± 16.0 57.2 ± 12.3 0.031 54.5 ± 14.9 56.5 ± 13.5 0.388
Female sex 68 (36.0) 30 (30.6) 0.437 13 (26.0) 12 (24.0) > 0.999
Body mass index, kg/m2, mean ± SD 22.5 ± 3.5 22.5 ± 3.5 0.938 22.2 ± 3.1 22.5 ± 3.4 0.664
SOFA score 9.0 ± 3.0 10.6 ± 2.9 < 0.001 10.0 ± 3.0 10.1 ± 2.9 0.865
ICU admission 89 (47.1) 95 (96.9) < 0.001 35 (70.0) 48 (96.0) 0.002
Underlying disease 0.079    0.412
  Acute myeloid/lymphoblastic leukemia 90 (47.6) 36 (36.7)   24 (48.0) 18 (36.0)  
  Lymphoma 45 (23.8) 19 (19.4)   11 (22.0) 10 (20.0)  
  Solid malignancy 35 (18.5) 24 (24.5)   10 (20.0) 11 (22.0)  
  Other hematologic disordersa 16 (8.5) 14 (14.3)   3 (6.0) 9 (18.0)  
  No hematologic/oncologic disorders 3 (1.6) 5 (5.1)   2 (4.0) 2 (4.0)  
Cause of neutropenia 0.791    0.750
  Chemotherapy 150 (79.4) 74 (75.5)   37 (74.0) 36 (72.0)  
  Hematologic malignancy 30(15.9) 17 (17.4)   9 (18.0) 11 (22.0)  
  Sepsis-induced 7 (3.7) 6 (6.1)   3 (6.0) 3 (6.0)  
  Drug-induced 2 (1.1) 1 (1.0)   1 (2.0) 0 (0.0)  
Cause of septic shock < 0.001    0.596
  Pneumonia 42 (22.2) 48 (49.0)   19 (38.0) 22 (44.0)  
  Unknown 59 (31.2) 15 (15.3)   8 (16.0) 10 (20.0)  
  Bacteremia or fungemia 56 (29.6) 21 (21.4)   15 (30.0) 10 (20.0)  
  GI origin 24 (12.7) 11 (11.2)   7 (14.0) 5 (10.0)  
  Others 8 (4.2) 3 (3.1)   1 (2.0) 3 (6.0)  
Vasopressor requirement
  Vasopressin 62 (32.8) 90 (91.8) < 0.001 42 (84.0) 42 (84.0) > 0.999
  Epinephrine 2 (1.1) 40 (40.8) < 0.001 2 (4.0) 2 (4.0) > 0.999
Mechanical ventilation 45 (23.8) 80 (81.6) < 0.001 21 (42.0) 34 (68.0) 0.016
Bacteremia 95 (50.3) 54 (55.1) 0.514 29 (58.0) 20 (40.0) 0.124
Duration of neutropenia, days, mean ± SD 12.4 ± 15.7 8.4 ± 12.4 0.019 11.7 ± 17.0 8.7 ± 14.3 0.292
Recovery of neutropenia 129 (68.3) 58 (59.2) 0.162 28 (56.0) 33 (66.0) 0.404
  1. Data are presented as numbers (%) and mean ± standard deviation
  2. aOther hematologic disorders include aplastic anemia, hemophagocytic lymphohistiocytosis, multiple myeloma, myelodysplastic syndrome, progressive myelofibrosis, and leukemia other than acute myeloid leukemia and acute lymphoblastic leukemia
  3. SOFA, sequential organ failure assessment; ICU, intensive care unit; GI, gastrointestinal