Annals of Hematology

, Volume 98, Issue 3, pp 783–785 | Cite as

Severe hemolytic anemia due to combined α thalassemia and de novo Hemoglobin Sabine

  • XinPing Chen
  • JunJie Hu
  • Juan Zhu
  • WeiHua Xu
  • HongXia Yao
  • AiZhu Wu
  • MeiFang Xiao
  • Zhe Lu
  • LiYan YinEmail author
  • ShengMiao FuEmail author
Letter to the Editor

Dear Editor,

Hb Sabine has been reported in eight individuals with severe hemolytic anemia so far [ 1, 2, 3, 4, 5, 6, 7], and these affected patients are all Caucasian origin. Here, we reported a new case of de novo Hb Sabine in a 4-year-old boy of Chinese nationality, who simultaneously carried an α thalassemia deletion. The child was first referred to the hospital because of severe influenza-like illness in June 2013 when he was 4 months old. He also had been presenting with pallor as well as fatigue since birth. Bone marrow cell morphology showed significantly hyperplastic erythropoiesis. Hematological tests were performed by using SysmexXN-1000 Hematology System. The hematological data of the proband are shown in Fig.  1 a. We noted that the child’s mother had a history of mild anemia and thus hypothesized that the child might be a typical patient with thalassemia. DNA was extracted from peripheral blood samples of the proband and his parents. Genetic analysis of thalassemia was...



Special fund for application technology and demonstration and promotion of Hainan (No. ZDXM2015071).

Compliance with ethical standards

Informed consent was obtained from the parents of the patient.

Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources, Institute of Tropical Agriculture and ForestryHainan UniversityHaikouChina
  2. 2.Department of Central Laboratory, Key Laboratory of Cellular and Molecular Genetic Transformation of Hainan Province MedicineHainan Province People’s HospitalHaikouChina
  3. 3.Department of HematologyHainan Province People’s HospitalHaikouChina
  4. 4.Department of Clinical LaboratoryMaternal and Child Health Hospital of Hainan ProvinceHaikouChina

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