Severe hemolytic anemia due to combined α thalassemia and de novo Hemoglobin Sabine
Letter to the Editor
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Hb Sabine has been reported in eight individuals with severe hemolytic anemia so far [ 1, 2, 3, 4, 5, 6, 7], and these affected patients are all Caucasian origin. Here, we reported a new case of de novo Hb Sabine in a 4-year-old boy of Chinese nationality, who simultaneously carried an α thalassemia deletion. The child was first referred to the hospital because of severe influenza-like illness in June 2013 when he was 4 months old. He also had been presenting with pallor as well as fatigue since birth. Bone marrow cell morphology showed significantly hyperplastic erythropoiesis. Hematological tests were performed by using SysmexXN-1000 Hematology System. The hematological data of the proband are shown in Fig. 1 a. We noted that the child’s mother had a history of mild anemia and thus hypothesized that the child might be a typical patient with thalassemia. DNA was extracted from peripheral blood samples of the proband and his parents. Genetic analysis of thalassemia was...
Special fund for application technology and demonstration and promotion of Hainan (No. ZDXM2015071).
Compliance with ethical standards
Informed consent was obtained from the parents of the patient.
Conflict of interest
The authors declare that they have no conflicts of interest.
- 1.Kollia P, Kalamaras A, Chassanidis C, Samara M, Vamvakopoulos NK, Radmilovic M, Pavlovic S, Papadakis MN, Patrinos GP (2008) Compound heterozygosity for the Cretan type of non-deletional hereditary persistence of fetal hemoglobin and beta-thalassemia or Hb Sabine confirms the functional role of the Agamma -158 C>T mutation in gamma-globin gene transcription. Blood Cells Mol Dis 41:263–264CrossRefGoogle Scholar
- 4.Gasperini D, Galanello R, Melis MA, Iannelli S, Giordano P, Bernini LF, Cao A (1992) Hemoglobin Sabine [beta 91 (F7) Leu-->Pro]: occurrence in a Sardinian individual with hemolytic anemia and inclusion bodies. Haematologica 77:381–383Google Scholar
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