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Annals of Hematology

, Volume 98, Issue 3, pp 787–788 | Cite as

Giant cellulitis-like Sweet syndrome as an initial clinical presentation of acute myeloblastic leukemia with t(6;9)(p23;q34): DEK-CAN and internal duplications of FMS-like tyrosine kinase 3

  • Shuhei OkuyamaEmail author
  • Toshiya Nito
  • Naoki Yanagawa
  • Katsushi Tajima
Letter to the Editor
  • 151 Downloads

Dear Editor,

A 56-year-old female farmer knocked her right knee against the ground and suffered from stinging pain, while she was working in a rice field. The next day, she developed a painful erythematous eruption on the right knee. She consulted a dermatologist and was diagnosed with cellulitis, and was treated with flomoxef antibiotic orally. However, on the following day, the right knee was still painfully inflamed, and she was transferred to a local hospital. On admission, she presented with an extensive cellulitis-like eruption on the right leg and mild fever. She had a history of sub-total gastrectomy, due to gastric cancer without chemotherapy 19 years ago. Her laboratory findings and clinical course are described in Fig.  1. A computed tomography or magnetic resonance image showed subcutaneous to fascia lesions without fluid formation and mild edematous swelling with multiple thrombophlebitis in the right leg. Intensive treatments, including administrations of meropenem,...

Notes

Funding information

This work was supported by a grant-in-aid for scientific research, KAKENHI Grant Number 80292423 (K. Tajima), from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from the patient included in this article.

References

  1. 1.
    Surovy AM, Pelivani N, Hegyi I, Buettiker U, Beltraminelli H, Borradori L (2013) Giant cellulitis-like Sweet Syndrome, a new variant of neutrophilic dermatosis. JAMA Dermatol 149(1):79–83.  https://doi.org/10.1001/2013.jamadermatol.548 CrossRefPubMedGoogle Scholar
  2. 2.
    Kaminska EC, Nwaneshiudu AI, Ruiz de Luzuriaga A, Tsoukas M, Bolotin D (2014) Giant cellulitis-like Sweet syndrome in the setting of autoimmune disease. J Am Acad Dermatol 71(3):e94–e95.  https://doi.org/10.1016/j.jaad.2014.03.025 CrossRefPubMedGoogle Scholar
  3. 3.
    Ozdogu H, Yeral M, Boga C (2017) An unusual giant leg ulcer as a rare presentation of Sweet’s syndrome in a patient with hairy cell leukemia successfully managed by splenectomy. Turk J Haematol 34(3):270–271.  https://doi.org/10.4274/tjh.2016.0416 CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Rochet NM, Chavan RN, Cappel MA, Wada DA, Gibson LE (2013) Sweet syndrome: clinical presentation, associations, and response to treatment in 77 patients. J Am Acad Dermatol 69(4):557–564.  https://doi.org/10.1016/j.jaad.2013.06.023 CrossRefPubMedGoogle Scholar
  5. 5.
    Kazmi SM, Pemmaraju N, Patel KP, Cohen PR, Daver N, Tran KM, Ravandi F, Duvic M, Garcia-Manero G, Pierce S, Nazha A, Borthakur G, Kantarjian H, Cortes J (2015) Characteristics of Sweet Syndrome in patients with acute myeloid leukemia. Clin Lymphoma Myeloma Leuk 15(6):358–363.  https://doi.org/10.1016/j.clml.2014.12.009 CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of HematologyYamagata Prefectural Central HospitalYamagataJapan
  2. 2.Department of OrthopedicsYamagata Prefectural Central HospitalYamagataJapan
  3. 3.Department of PathologyYamagata Prefectural Central HospitalYamagataJapan

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