Annals of Hematology

, Volume 98, Issue 3, pp 801–803 | Cite as

Blastic plasmacytoid dendritic cell neoplasm with response to pralatrexate

  • Shuku SatoEmail author
  • Eri Tanaka
  • Yotaro Tamai
Letter to the Editor

Dear Editor,

We encountered a 75-year-old Japanese male patient with a 1-year history of multiple brown nodules appearing on the abdomen and back. Skin lesion biopsies suggested cutaneous T cell lymphoma (CTCL). Computed tomography scans revealed no evidence of lymphadenopathy, and bone marrow specimens revealed no evidence of lymphoma invasion. The patient was treated with 6 cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisone) chemotherapy that was administered every 21 days. The nodules initially responded to the CHOP chemotherapy; however, after 3 months, the skin lesions worsened, with multiple, new, larger, brown nodules developing on the back (Fig.  1a). A subsequent skin lesion biopsy of a nodule located on the back revealed recurrent CTCL. Therefore, we attempted a weekly treatment of pralatrexate at a dosage of 30 mg/m 2, intravenously for 3 min, with folate and vitamin B12 supplements. Significant improvement in the tumors was seen after a single course...


Compliance with ethical standards

Informed consent was obtained from the patient for the treatment. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of HematologyShonan Kamakura General HospitalKamakuraJapan
  2. 2.Division of Internal MedicineHayama Heart CenterHayamaJapan

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