Annals of Hematology

, Volume 98, Issue 3, pp 789–791 | Cite as

Management of an adult patient with sickle cell disease and acute chest syndrome by veno-venous extracorporeal membrane oxygenation

  • O. Al-Sawaf
  • P. Köhler
  • D. A. Eichenauer
  • B. Böll
  • M. Kochanek
  • A. Shimabukuro-VornhagenEmail author
Letter to the Editor

Dear Editor,

A 21-year-old male patient of a sub-Saharan African descent with homozygote sickle cell disease (SCD) on hydroxyurea therapy was transferred from another hospital to our institution with acute respiratory failure. He had a history of multiple vaso-occlusive crises, salmonella sepsis with multiple organ failure, intracranial bleedings requiring surgical evacuation and bone infarction of hips and vertebral bodies. Initially, he had presented at his local hospital with a pain crisis and was treated with fluids and intravenous opioids. Nonetheless, he developed an increasing loss of vigilance and hypoxemia as well as purulent sputum within 1 day. Anti-infective therapy with piperacillin/tazobactam was initiated. Lab chemistry showed intravascular haemolysis, thrombocytopenia and acute renal failure. Upon referral to our institution, the patient was intubated due to respiratory failure and required norepinephrine at a dose of 1000 μg/h to maintain an acceptable mean arterial...


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department I of Internal Medicine, Critical Care MedicineUniversity Hospital of CologneCologneGermany

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