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The impact of chronic myeloid leukemia on employment: the French prospective study

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Abstract

Patients with chronic myeloid leukemia treated with breakpoint cluster region-Abelson tyrosine kinase inhibitors are likely to survive in excess of 20 years after diagnosis. New challenges appear as we consider life after the disease, including professional challenges and the social reintegration of patients. The purpose of this study was to determine the impact of chronic myeloid leukemia on employment within 2 years after diagnosis. This prospective, observational study included patients diagnosed with chronic myeloid leukemia and treated with a tyrosine kinase inhibitor. Two populations were defined as patients who reported modifications in their professional activity during the study (Acti-Pro+) and patients who did not report a modification (Acti-Pro−). Cancer survivors received a self-assessment questionnaire. The primary endpoint was to determine the professional status of patients. One hundred patients completed the questionnaire. Sixty-six patients out of 100 reported professional activity within 2 years after their diagnosis. During the 2 years after the diagnosis, 65.2% (95% confidence interval (CI), 53.7–76.7) of patients faced modifications in their professional activity due to chronic myeloid leukemia or adverse effects of drug treatments (group Acti-Pro+); in contrast, 34.8% of patients did not report any impact on their occupational activity (group Acti-Pro−). Among modifications to work organization, a change in the number of working hours was the most represented. Other modifications comprised changes in status or work pace. A majority of chronic myeloid leukemia patients face professional consequences of their disease and treatments. Our findings suggest that adverse drug reactions are a major factor affecting the occurrence of work modifications in this context.

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Funding

This work received support from the National Research Agency (Agence Nationale de la Recherche (ANR)) for “investissement d’avenir” (“Investment in the Future”) (ANR-11-PHUC-001; CAPTOR). The financial support was used to perform the data collection. The ANR was not involved in the design of the study, analysis, interpretation of data, or writing the manuscript.

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Author notes

  1. Sandra De Barros and Flora Vayr contributed equally to this work.

Authors and Affiliations

  1. Department of Clinical Pharmacology, Toulouse University Hospital, Toulouse, France

    Sandra De Barros, Fabien Despas, Mathilde Strumia & Clémentine Podevin

  2. Department of Occupational Diseases, Toulouse University Hospital, Bâtiment Turiaf, Place du Dr Baylac, 31059, Toulouse Cedex 9, France

    Flora Vayr, Jean-Marc Soulat & Fabrice Herin

  3. Laboratory of Clinical Pharmacology, Université Toulouse III, Toulouse, France

    Fabien Despas

  4. INSERM UMR1027 (The French National Institute of Health and Medical Research), Université Toulouse III, Toulouse, France

    Fabien Despas, Jean-Marc Soulat, Guy Laurent & Fabrice Herin

  5. Department of Hematology, Toulouse University Hospital, IUCT-O, Toulouse, France

    Martin Gauthier, Guy Laurent & Françoise Huguet

  6. Hematology Laboratory, Toulouse University Hospital, Toulouse, France

    Eric Delabesse

Authors
  1. Sandra De Barros
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  2. Flora Vayr
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  7. Eric Delabesse
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  8. Jean-Marc Soulat
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  9. Guy Laurent
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  11. Fabrice Herin
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Contributions

SDB, FV, FD, FHu, and FHe created the study concept and design. CP, MG, MS, and FD performed the acquisition of data. SDB, FV, FHu, FD, JMS, ED, GL, and FHe performed the analysis and interpretation of data. SDB, FV, FHu, and FHe wrote the draft of the manuscript. FD, ED, JMS, GL, and FHu undertook critical revision of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Fabrice Herin.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval and consent to participate

All procedures performed in the study that involved human participants were in accordance with the ethical standards of the institutional committee, national research committee, and the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Availability of data and material

The datasets generated and analyzed during the study are available from the corresponding author on reasonable request.

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De Barros, S., Vayr, F., Despas, F. et al. The impact of chronic myeloid leukemia on employment: the French prospective study. Ann Hematol 98, 615–623 (2019). https://doi.org/10.1007/s00277-018-3549-5

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  • DOI: https://doi.org/10.1007/s00277-018-3549-5

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