Skip to main content
SpringerLink
Log in

Localized pain-causing JAK2-V617F-positive myeloproliferation with normal peripheral blood values

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Aboudola S, Murugesan G, Szpurka H, Ramsingh G, Zhao X, Prescott N, Tubbs RR, Maciejewski JP, Hsi ED (2007) Bone marrow phospho-STAT5 expression in non-CML chronic myeloproliferative disorders correlates with JAK2 V617F mutation and provides evidence of in vivo JAK2 activation. Am J Surg Pathol 31(2):233–239. https://doi.org/10.1097/01.pas.0000213338.25111.d3

    Article  PubMed  Google Scholar 

  2. Meier C, Hoeller S, Bourgau C, Hirschmann P, Schwaller J, Went P, Pileri SA, Reiter A, Dirnhofer S, Tzankov A (2009) Recurrent numerical aberrations of JAK2 and deregulation of the JAK2-STAT cascade in lymphomas. Mod Pathol 22(3):476–487. https://doi.org/10.1038/modpathol.2008.207

    Article  CAS  PubMed  Google Scholar 

  3. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J (2017) WHO classification of tumours of haematopoietic and lymphoid tissues, Revised 4th edn. International Agency for Research on Cancer, Lyon

  4. Kiladjian JJ, Cervantes F, Leebeek FW, Marzac C, Cassinat B, Chevret S, Cazals-Hatem D, Plessier A, Garcia-Pagan JC, Darwish Murad S, Raffa S, Janssen HL, Gardin C, Cereja S, Tonetti C, Giraudier S, Condat B, Casadevall N, Fenaux P, Valla DC (2008) The impact of JAK2 and MPL mutations on diagnosis and prognosis of splanchnic vein thrombosis: a report on 241 cases. Blood 111(10):4922–4929. https://doi.org/10.1182/blood-2007-11-125328

    Article  CAS  PubMed  Google Scholar 

  5. Fujimi A, Kanisawa Y, Minami S, Kamihara Y, Iwasaki S (2014) Focal 18F-FDG uptake in bone marrow on PET/CT in a patient with JAK2 mutation without overt myeloproliferative neoplasm. Int J Hematol 99(1):1–3. https://doi.org/10.1007/s12185-013-1473-y

    Article  PubMed  Google Scholar 

  6. Mead AJ, Mullally A (2017) Myeloproliferative neoplasm stem cells. Blood 129(12):1607–1616. https://doi.org/10.1182/blood-2016-10-696005

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Nielsen C, Birgens HS, Nordestgaard BG, Kjaer L, Bojesen SE (2011) The JAK2 V617F somatic mutation, mortality and cancer risk in the general population. Haematologica 96(3):450–453. https://doi.org/10.3324/haematol.2010.033191

    Article  PubMed  Google Scholar 

  8. Nielsen C, Bojesen SE, Nordestgaard BG, Kofoed KF, Birgens HS (2014) JAK2V617F somatic mutation in the general population: myeloproliferative neoplasm development and progression rate. Haematologica 99(9):1448–1455. https://doi.org/10.3324/haematol.2014.107631

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We would like to thank Professor Radek Skoda for critically reading the manuscript.

Author information

Authors and Affiliations

  1. Institute of Pathology, University Hospital Basel, Schönbeinstrasse 40, CH-4031, Basel, Switzerland

    Magdalena M. Gerlach, Stefan Dirnhofer & Alexandar Tzankov

  2. Department for Hematology, University Hospital Basel, Petersgraben 4, CH-4031, Basel, Switzerland

    Christian Arranto

Authors
  1. Magdalena M. Gerlach
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christian Arranto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stefan Dirnhofer
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alexandar Tzankov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Magdalena M. Gerlach.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the patient.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gerlach, M.M., Arranto, C., Dirnhofer, S. et al. Localized pain-causing JAK2-V617F-positive myeloproliferation with normal peripheral blood values. Ann Hematol 97, 2265–2266 (2018). https://doi.org/10.1007/s00277-018-3363-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-018-3363-0

Search

Navigation