Annals of Hematology

, Volume 97, Issue 11, pp 2265–2266 | Cite as

Localized pain-causing JAK2-V617F-positive myeloproliferation with normal peripheral blood values

  • Magdalena M. Gerlach
  • Christian Arranto
  • Stefan Dirnhofer
  • Alexandar Tzankov
Letter to the Editor

Dear Editor,

Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) characterized morphologically by panmyelosis with erythroid predominance and elevated red cell parameters in peripheral blood. In approximately 98% of cases, a somatic mutation in the tyrosine kinase JAK2 gene can be found ( JAK2-V617F or JAK2 exon 12). Here, we report on a 47-year-old man who was admitted to our hospital because of isolated bone pain in lumbar vertebra one (L1). FDG-PET revealed increased activity in vertebral body L1 (Fig.  1a). Therefore, a surgical biopsy was taken. Histopathologically, marked hypercellularity with erythroid hyperplasia, increased, partially clustered megakaryopoiesis with nuclear atypia (Fig.  1b) and positivity for phosphorylated STAT5 (pSTAT5) (Fig.  1c) as well as left-shifted myelopoiesis with eosinophilia were observed, all together compatible with MPN. Therefore, a hematologic workup was performed. Peripheral blood values were normal except of a slightly decreased...



We would like to thank Professor Radek Skoda for critically reading the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the patient.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Magdalena M. Gerlach
    • 1
  • Christian Arranto
    • 2
  • Stefan Dirnhofer
    • 1
  • Alexandar Tzankov
    • 1
  1. 1.Institute of PathologyUniversity Hospital BaselBaselSwitzerland
  2. 2.Department for HematologyUniversity Hospital BaselBaselSwitzerland

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