Skip to main content
SpringerLink
Log in

Eculizumab treatment for ischemic enteritis accompanied with paroxysmal nocturnal hemoglobinuria: a case report and literature review

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Nishimura J, Kanakura Y, Ware RE, Shichishima T, Nakakuma H, Ninomiya H, Decastro CM, Hall S, Kanamaru A, Sullivan KM, Mizoguchi H, Omine M, Kinoshita T, Rosse WF (2004) Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. Medicine (Baltimore) 83(3):193–207

    Article  Google Scholar 

  2. Hill A, Kelly RJ, Hillmen P (2013) Thrombosis in paroxysmal nocturnal hemoglobinuria. Blood 121(25):4985–4996

    Article  PubMed  CAS  Google Scholar 

  3. González FA, Villegas A, Osorio S, Seri C, Fontanes E, Pérez B, Díaz Mediavilla J (2012) Thrombosis and severe asthenia as priority manifestations in paroxysmal nocturnal haemoglobinuria. Ann Hematol 91(9):1495–1496

    Article  PubMed  Google Scholar 

  4. Grigg A, Brown M, Szer J (2010) Durable resolution of recurrent microvascular small bowel ischaemia and severe abdominal pain by eculizumab in paroxysmal nocturnal haemoglobinuria. Intern Med J 40(11):794–795

    Article  PubMed  CAS  Google Scholar 

  5. Hino A, Yamashita Y, Yamaguchi M, Azenishi Y (2014) Recurrent and progressive abdominal pain and enteritis in a Japanese patient with paroxysmal nocturnal hemoglobinuria. Case Rep Hematol 2014:310750

    PubMed  PubMed Central  Google Scholar 

  6. Blum SF, Gardner FH (1966) Intestinal infarction in paroxysmal nocturnal hemoglobinuria. N Engl J Med 274(20):1137–1138

    Article  Google Scholar 

  7. Lee BC (1973) Paroxysmal nocturnal hemoglobinuria presenting as an acute abdominal surgery. Br J Radiol 46(546):467–469

    Article  PubMed  CAS  Google Scholar 

  8. Doukas MA, DiLorenzo PE, Mohler DN (1984) Intestinal infarction caused by paroxysmal nocturnal hemoglobinuria. Am J Hematol 16(1):75–81

    Article  PubMed  CAS  Google Scholar 

  9. Williamson LM, Johnstone JM, Preston FE (1987) Microvascular thrombosis of the bowel in paroxysmal nocturnal hemoglobinuria. J Clin Pathol 40(8):930–931

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. Quentin V, Dinasquet M, Rioux-Leclercq N, de Lajarte-Thirouard AS, Lotrian D, Lamy T, Bernard M, Olivié D, Gosselin M, Bretagne JF, Heresbach D (2003) Hémoglobinurie paroxystique nocturne avec ischémie digestive compliquée de perforation de l’intestin grêle. Gastroenterol Clin Biol 27(10):927–931

    PubMed  Google Scholar 

  11. Ramus J, McPherson GA (2003) Recurrent bowel infarction in paroxysmal nocturnal hemoglobinuria. J R Soc Med 96(8):406–407

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  12. Hertz IH, Keller RJ (1981) Paroxysmal nocturnal hemoglobinuria: small bowel findings. Am J Roentgenol 136(1):204–205

    Article  CAS  Google Scholar 

  13. Zapata R, Mella J, Rollan A (1998) Intestinal ischemia complicating paroxysmal nocturnal hemoglobinuria. Gastrointest Endosc 47(2):184–186

    Article  PubMed  CAS  Google Scholar 

  14. Sivakumaran S, Hoyles R, Hunter J, Middleton S (1999) Paroxysmal nocturnal hemoglobinuria mimicking Crohn’s disease. Gut 44(6):889

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. Adams T, Fleischer D, Marino G, Rusnock E, Li L (2002) Gastrointestinal involvement in paroxysmal nocturnal hemoglobinuria: first report of electron microscopic findings. Dig Dis Sci 47(1):58–64

    Article  PubMed  CAS  Google Scholar 

  16. Torres J, De Vroey B, Noël MP, Notteghem B, Colombel JF (2010) Recurrent small bowel ischemia in a patient with paroxysmal nocturnal hemoglobinuria. Nat Rev Gastroenterol Hepatol 7(7):410–414

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Megumi Yasunaga, Kazuki Taoka, Kumi Nakazaki & Mineo Kurokawa

  2. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Hayato Nakagawa, Atsuo Yamada & Kazuhiko Koike

  3. Department of Pathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Hiroyuki Abe & Masashi Fukayama

  4. Department of Clinical Laboratory, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Masahiro Jona

  5. Department of Clinical Laboratory Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Masako Nishikawa & Yutaka Yatomi

  6. Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Mineo Kurokawa

Authors
  1. Megumi Yasunaga
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kazuki Taoka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hayato Nakagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Atsuo Yamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hiroyuki Abe
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masahiro Jona
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Masako Nishikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kumi Nakazaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yutaka Yatomi
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Masashi Fukayama
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Kazuhiko Koike
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Mineo Kurokawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mineo Kurokawa.

Ethics declarations

Conflicts of interest

Dr. Kurokawa reports grants and personal fees from Alexion Pharmaceuticals, Inc. and Asahi Kasei Pharma Corporation, and personal fees from Shionogi & Co., Ltd. outside the submitted work. The other authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from the patient for being included in this case report.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yasunaga, M., Taoka, K., Nakagawa, H. et al. Eculizumab treatment for ischemic enteritis accompanied with paroxysmal nocturnal hemoglobinuria: a case report and literature review. Ann Hematol 97, 1513–1515 (2018). https://doi.org/10.1007/s00277-018-3286-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-018-3286-9

Search

Navigation