Abbreviations
- HCT:
-
hematopoietic cell transplantation
- JAK2:
-
Janus kinase 2
- JAK-STAT:
-
Janus kinase-signal transducer and activator of transcription
- PD-L1/2:
-
programmed cell-death ligand ½
- PMBL:
-
primary mediastinal B-cell lymphoma
References
Gaulard P, Harris NL, Pileri SA. (2017) Primary mediastinal (thymic) large B-cell lymphoma. In Swerdlow SH, Camp E, Harris NL, et al WHO classification of tumours of haematopoeitic and lymphoid tissues Revised 4th ed International Agency for Research on Cancer:314–316
Savage KJ, Monti S, Kutok JL, Cattoretti G, Neuberg D, de Leval L, Kurtin P, Dal Cin P, Ladd C, Feuerhake F, Aguiar RC, Li S, Salles G, Berger F, Jing W, Pinkus GS, Habermann T, Dalla-Favera R, Harris NL, Aster JC, Golub TR, Shipp MA (2003) The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood 102(12):3871–3879. https://doi.org/10.1182/blood-2003-06-1841
Green MR, Monti S, Rodig SJ, Juszczynski P, Currie T, O'Donnell E, Chapuy B, Takeyama K, Neuberg D, Golub TR, Kutok JL, Shipp MA (2010) Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood 116(17):3268–3277. https://doi.org/10.1182/blood-2010-05-282780
Steidl C, Gascoyne RD (2011) The molecular pathogenesis of primary mediastinal large B-cell lymphoma. Blood 118(10):2659–2669. https://doi.org/10.1182/blood-2011-05-326538
Dunleavy K, Pittaluga S, Maeda LS, Advani R, Chen CC, Hessler J, Steinberg SM, Grant C, Wright G, Varma G, Staudt LM, Jaffe ES, Wilson WH (2013) Dose-adjusted EPOCH-rituximab therapy in primary mediastinal B-cell lymphoma. N Engl J Med 368(15):1408–1416. https://doi.org/10.1056/NEJMoa1214561
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, Lister TA, Alliance, Australasian Leukaemia and Lymphoma Group., Eastern Cooperative Oncology Group., European Mantle Cell Lymphoma Consortium., Italian Lymphoma Foundation., European Organisation for Research., Treatment of Cancer/Dutch Hemato-Oncology Group., Grupo Español de Médula Ósea., German High-Grade Lymphoma Study Group., German Hodgkin's Study Group., Japanese Lymphorra Study Group., Lymphoma Study Association., NCIC Clinical Trials Group., Nordic Lymphoma Study Group., Southwest Oncology Group., United Kingdom National Cancer Research Institute (2014) Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol 32(27):3059–3068. https://doi.org/10.1200/JCO.2013.54.8800
Zinzani PL, Pellegrini C, Chiappella A, di Rocco A, Salvi F, Cabras MG, Argnani L, Stefoni V (2017) Brentuximab vedotin in relapsed primary mediastinal large B-cell lymphoma: results from a phase 2 clinical trial. Blood 129(16):2328–2330. https://doi.org/10.1182/blood-2017-01-764258
Kim JS, Kang HJ, Dong S et al (2016) The efficacy of JAK2 inhibitor in heavily pretreated classical Hodgkin lymphoma: a prospective pilot study of ruxolitinib in relapsed or refractory classical Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood 128:1820
Zinzani PL, Ribrag V, Moskiwitz CH et al (2017) Safety and tolerability of pembrolizumab in patients with relapsed/refractory primary mediastinal large B-cell lymphoma. Blood 130(3):267–270. https://doi.org/10.1182/blood-2016-12-758383
Zeiser R, Burchert A, Lengerke C, Verbeek M, Maas-Bauer K, Metzelder SK, Spoerl S, Ditschkowski M, Ecsedi M, Sockel K, Ayuk F, Ajib S, de Fontbrune FS, Na IK, Penter L, Holtick U, Wolf D, Schuler E, Meyer E, Apostolova P, Bertz H, Marks R, Lübbert M, Wäsch R, Scheid C, Stölzel F, Ordemann R, Bug G, Kobbe G, Negrin R, Brune M, Spyridonidis A, Schmitt-Gräff A, van der Velden W, Huls G, Mielke S, Grigoleit GU, Kuball J, Flynn R, Ihorst G, Du J, Blazar BR, Arnold R, Kröger N, Passweg J, Halter J, Socié G, Beelen D, Peschel C, Neubauer A, Finke J, Duyster J, von Bubnoff N (2015) Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey. Leukemia 29(10):2062–2068. https://doi.org/10.1038/leu.2015.212
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MN designed the paper. MN, TM, and GH treated the patient. AD and RK provided pathological review. AS, LV, and AB performed FISH analysis. All authors contributed in writing the manuscript. All authors read and approved the final manuscript.
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Nijland, M., van Meerten, T., Seitz, A. et al. Combined PD-1 and JAK1/2 inhibition in refractory primary mediastinal B-cell lymphoma. Ann Hematol 97, 905–907 (2018). https://doi.org/10.1007/s00277-018-3233-9
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DOI: https://doi.org/10.1007/s00277-018-3233-9