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Annals of Hematology

, Volume 96, Issue 5, pp 711–718 | Cite as

Clinical impact of galectin-3 in newly diagnosed t (15;17)(q22;q21)/PML-RARa acute promyelocytic leukemia treated with all-trans retinoic acid and arsenic trioxide-based regimens

  • Na Gao
  • Xue-Xia Wang
  • Jian-Rong Sun
  • Wen-Zheng Yu
  • Xi-Zhi Li
Original Article

Abstract

Increased galectin-3 expression has been currently showed to be associated with poor prognosis in some hematological malignancies, such as acute myeloid leukemia, diffuse large B cell lymphoma. However, little is known about the clinical significance of galectin-3 in patients with acute promyelocytic leukemia (APL). We investigated the concentration of serum galectin-3 and characterized the relationship between galectin-3 and outcome in patients with APL. Higher galectin-3 levels were detected in patients with APL compared with the healthy controls (p < 0.001). Higher galectin-3 levels were closely associated with older ages (p < 0.001), the medical history of psoriasis (p = 0.036), coagulopathy (p = 0.042), and CD34 expression (p = 0.004). Compared with patients with lower galectin-3 levels, those with higher galectin-3 levels had significant shorter overall survival (p = 0.028) and relapse-free survival (p = 0.001). Multivariate analysis showed that serum galectin-3 was an independent unfavorable factor for relapse-free survival in patients with APL treated with all-trans retinoic acid and arsenic trioxide-based frontline therapy. Clinical impact of galectin-3 should be further investigated in patients with APL.

Keywords

Acute promyelocytic leukemia Galectin-3 Prognosis Relapse Overall survival 

Notes

Acknowledgements

This work was supported by the Medical and Health science and Technology Development Program (2015WS0508) of Shandong and Binzhou Medical University Scientific Research Fund (BY2013KJ38).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

277_2017_2948_MOESM1_ESM.docx (35 kb)
Figure S1 (DOCX 34 kb)
277_2017_2948_MOESM2_ESM.docx (36 kb)
Figure S2 (DOCX 35 kb)
277_2017_2948_MOESM3_ESM.docx (34 kb)
Figure S3 (DOCX 33 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Na Gao
    • 1
  • Xue-Xia Wang
    • 1
  • Jian-Rong Sun
    • 1
  • Wen-Zheng Yu
    • 1
  • Xi-Zhi Li
    • 2
  1. 1.Department of hematologyBinzhou Medical University HospitalBinzhouChina
  2. 2.Department of nephrologyBinzhou Medical University HospitalBinzhouChina

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