Glucose-6-phosphate dehydrogenase deficiency and risk of diabetes: a systematic review and meta-analysis
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Emerging epidemiological evidence suggests that patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency may have a higher risk of developing diabetes. The aim of the review was to synthesise the evidence on the association between G6PD deficiency and diabetes. A systematic search on Medline, EMBASE, AMED and CENTRAL databases for studies published between January 1966 and September 2016 that assessed the association between G6PD deficiency and diabetes was conducted. This was supplemented by a review of the reference list of retrieved articles. We extracted data on study characteristics, outcomes and performed an assessment on the methodological quality of the studies. A random-effects model was used to compute the summary risk estimates. Fifteen relevant publications involving 949,260 participants were identified, from which seven studies contributed to the meta-analysis. G6PD deficiency was associated with a higher odd of diabetes (odds ratio 2.37, 95% confidence interval 1.50–3.73). The odds ratio of diabetes among men was higher (2.22, 1.31–3.75) compared to women (1.87, 1.12–3.12). This association was broadly consistent in the sensitivity analysis. Current evidence suggests that G6PD deficiency may be a risk factor for diabetes, with higher odds among men compared to women. Further research is needed to determine how G6PD deficiency moderates diabetes.
KeywordsGlucose-6-phosphate dehydrogenase deficiency Gender Diabetes Prevalence
The authors wish to thank Anthony Heymann of the University of Tel Aviv for sharing the information required from his studies.
SWHL, NML and YKL undertook the literature search and reviewed the abstracts and full articles. SWHL conceived the idea, drafted the initial manuscript and performed the statistical analysis. All authors designed the study, contributed to the discussion and critically reviewed the final manuscript.
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Conflict of interest
The authors declare that they have no conflict of interest.
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