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Radiofrequency Ablation of Parathyroid Adenoma: Results of a Retrospective Analysis of 60 Patients

  • Clinical Investigation
  • Non-Vascular Interventions
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Abstract

Purpose

To present the effectiveness and safety of radiofrequency ablation (RFA) in parathyroid adenoma (PTA).

Materials and Methods

In this retrospective study, 60 patients with a single PTA were evaluated for changes in biochemical and ultrasonographic features up to 6 months after RFA of the lesion. Adenomas were ablated with an alternative technique so called “Nik jet dissection” which incorporates full hydrodissection and polar artery coagulation. Complications as well as the variations in biochemical data and nodule volumes were analyzed between baseline measurements and at each follow-up interval data (first day, 1, 3, and 6 months after ablation) were analyzed.

Results

A significant reduction in serum intact parathyroid hormone and calcium levels was observed 6 months after ablation, with a mean difference of − 83.4 ± 104.1 pg/mL, p < 0.001, and − 0.29 ± 0.22 mmol/L, p < 0.001, respectively. Serum phosphorus levels increased significantly with a mean difference of 0.09 ± 0.19 mmol/L, p = 0.040 at the end of the follow up. We observed a significant volume reduction rate of parathyroid adenomas with 89 ± 20.8 percent, p < 0.001. Also, 51% of adenomas disappeared at the end of the follow up. In this study, two cases of hematoma and one case of transient hoarseness (grade 1 of the CIRSE classification) were encountered.

Conclusion

Our study showed that RFA with the alternative technique, called “Nik jet dissection” is a safe and effective modality in management of PTA. Therefore, we suggest expanding the indications for RFA in PTA management, especially when surgery is not feasible.

Level of Evidence

Level 3, Local non-random sample.

Graphical Abstract

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Acknowledgements

We would appreciate all participants in this study.

Funding

Not applicable.

Author information

Authors and Affiliations

  1. Hazrat Rasool Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran

    Haleh Chehrehgosha

  2. Tirad Imaging Institute, Tehran, Iran

    Hossein Chegini & Rambod Salouti

  3. Endocrinology Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran

    Iraj Heydari

  4. Department of Interventional Radiology and Radiation, Sciences Research Center, AJA University of Medical Sciences, Etemadzadeh St, West Fatemi St, Tehran, Tehran Province, 11366, Islamic Republic of Iran

    Hojat Ebrahiminik

  5. Radiology and Vascular Imaging, Amplatz Chair in Interventional Radiology, University of Minnesota, Minneapolis, USA

    Jafar Golzarian

Authors
  1. Haleh Chehrehgosha
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  2. Hossein Chegini
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  4. Hojat Ebrahiminik
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Corresponding author

Correspondence to Hojat Ebrahiminik.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

This retrospective study was endorsed by the Ethics Committee of Iran University of Medical Sciences (ethics code.R.IUMS.FMD.REC.1401.1050) and was consonant with the principles of the Declaration of Helsinki.

Informed Consent

Written informed consent was obtained from all patients before RF ablation.

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For this type of study consent for publication is not required.

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Chehrehgosha, H., Chegini, H., Heydari, I. et al. Radiofrequency Ablation of Parathyroid Adenoma: Results of a Retrospective Analysis of 60 Patients. Cardiovasc Intervent Radiol (2024). https://doi.org/10.1007/s00270-024-03725-w

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  • DOI: https://doi.org/10.1007/s00270-024-03725-w

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