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Extraluminal Recanalization for Biliary Duct-to-Duct Anastomotic Obstruction After Living Donor Liver Transplantation: Experience in Eight Patients

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Abstract

Purpose

To investigate clinical outcomes and safety of extraluminal recanalization for duct-to-duct anastomotic obstruction after living donor liver transplantation (LDLT).

Materials and Methods

Extraluminal recanalization was performed as a salvage procedure after failure of intraluminal cannulation in eight patients who underwent percutaneous transhepatic treatment of duct-to-duct anastomotic obstruction 11.0 ± 5.27 months after LDLT between October 2012 and April 2019. Technical details, safety, and outcomes of extraluminal recanalization were investigated.

Results

Total ten sessions of extraluminal recanalization were performed in the eight patients with the stiff backend of a 0.035 inch hydrophilic guide wire, 22-gauge Chiba needle, or Colapinto needle. Percutaneous common bile duct access was performed in three sessions to obtain a straight course for the puncture. There was one instance of subcapsular and intraparenchymal hematoma requiring placement of an additional drainage catheter and conservative treatment. During a follow-up period ranging from 18.4 to 100.7 months, the drainage catheter was removed in seven of the eight patients, including three patients who had recurrent stricture requiring repeat percutaneous treatment and one who underwent a routine change of an endoscopic retrograde biliary drainage catheter.

Conclusions

Extraluminal recanalization can be an effective and safe salvage procedure after failed intraluminal cannulation of duct-to-duct anastomotic obstruction in LDLT.

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References

  1. Akamatsu N, Sugawara Y, Hashimoto D. Biliary reconstruction, its complications and management of biliary complications after adult liver transplantation: a systematic review of the incidence, risk factors and outcome. Transpl Int. 2011;24(4):379–92.

    Article  Google Scholar 

  2. Chok KS, Lo CM. Biliary complications in right lobe living donor liver transplantation. Hepatol Int. 2016;10(4):553–8.

    Article  Google Scholar 

  3. Rao HB, Prakash A, Sudhindran S, Venu RP. Biliary strictures complicating living donor liver transplantation: problems, novel insights and solutions. World J Gastroenterol. 2018;24(19):2061–72.

    Article  Google Scholar 

  4. Nakamura T, Tanaka K, Kiuchi T, et al. Anatomical variations and surgical strategies in right lobe living donor liver transplantation: lessons from 120 cases. Transplantation. 2002;73(12):1896–903.

    Article  Google Scholar 

  5. Olthoff KM, Merion RM, Ghobrial RM, et al. Outcomes of 385 adult-to-adult living donor liver transplant recipients: a report from the A2ALL Consortium. Ann Surg. 2005;242(3):314–23 (discussion 323–315).

    Article  Google Scholar 

  6. Ko GY, Sung KB, Yoon HK, Kim KR, Gwon DI, Lee SG. Percutaneous transhepatic treatment of hepaticojejunal anastomotic biliary strictures after living donor liver transplantation. Liver Transplant. 2008;14(9):1323–32.

    Article  Google Scholar 

  7. Gwon DI, Sung KB, Ko GY, Yoon HK, Lee SG. Dual catheter placement technique for treatment of biliary anastomotic strictures after liver transplantation. Liver Transplant. 2011;17(2):159–66.

    Article  Google Scholar 

  8. Mukund A, Choudhury A, Das S, Pamecha V, Sarin SK. Salvage PTBD in post living donor liver transplant patients with biliary complications—a single centre retrospective study. Br J Radiol. 2020;93(1108):20191046.

    Article  Google Scholar 

  9. Choo SW, Shin SW, Do YS, et al. The balloon dilatation and large profile catheter maintenance method for the management of the bile duct stricture following liver transplantation. Korean J Radiol. 2006;7(1):41–9.

    Article  Google Scholar 

  10. Kulkarni CB, Prabhu NK, Kader NP, Rajeshkannan R, Pullara SK, Moorthy S. Percutaneous transhepatic techniques for management of biliary anastomotic strictures in living donor liver transplant recipients. Indian J Radiol Imaging. 2017;27(1):92–9.

    Article  Google Scholar 

  11. Kamiya S, Nagino M, Kanazawa H, et al. The value of bile replacement during external biliary drainage: an analysis of intestinal permeability, integrity, and microflora. Ann Surg. 2004;239(4):510–7.

    Article  Google Scholar 

  12. Kim EH, Lee HG, Oh JS, Chun HJ, Choi BG. Extraluminal recanalization of bile duct anastomosis obstruction after liver transplantation. J Vasc Interv Radiol. 2018;29(10):1466–71.

    Article  Google Scholar 

  13. Gwon DI, Ko GY, Ko HK, Yoon HK, Sung KB. Percutaneous transhepatic treatment using retrievable covered stents in patients with benign biliary strictures: mid-term outcomes in 68 patients. Dig Dis Sci. 2013;58(11):3270–9.

    Article  Google Scholar 

  14. Ye P, Zeng Q, Miao H, Pang H, Chen Y. Percutaneous treatment of benign biliary anastomotic strictures: retrievable covered self-expandable metal stent with fixation string versus large-bore catheters. J Vasc Interv Radiol. 2021;32(1):113–20.

    Article  Google Scholar 

  15. Battistel M, Senzolo M, Ferrarese A, et al. Biodegradable biliary stents for percutaneous treatment of post-liver transplantation refractory benign biliary anastomotic strictures. Cardiovasc Interv Radiol. 2020;43(1):749–55.

    Article  Google Scholar 

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Funding

This study was not supported by any funding.

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Correspondence to In Joon Lee.

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None of the authors has any conflict to disclose.

Ethical Approval

The protocol conformed to ethical guidelines of the World Medical Association Declaration of Helsinki and was approved by the Institutional Review Board of the National Cancer Center (No. NCC2021-0017).

Informed Consent

The requirement for informed consent from patients was waived owing to the retrospective nature of the study.

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Kim, H.B., Lee, I.J., Kim, S.H. et al. Extraluminal Recanalization for Biliary Duct-to-Duct Anastomotic Obstruction After Living Donor Liver Transplantation: Experience in Eight Patients. Cardiovasc Intervent Radiol 44, 1266–1272 (2021). https://doi.org/10.1007/s00270-021-02826-0

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  • DOI: https://doi.org/10.1007/s00270-021-02826-0

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