Lymphocytes, Neutrophils and the Response to Selective Internal Radiation Therapy: More Questions than Answers Yet

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Carr BI. Yttrium glass microspheres (Therasphere) for unresectable hepatocellular carcinoma: interim safety and survival data on 65 patients. Liver Transplant. 2004;10:S107–110. https://doi.org/10.1002/lt.20036.

    Article  Google Scholar 

  2. 2.

    Domouchtsidou A, Barsegian V, Mueller SP, et al. Impaired lymphocyte function in patients with hepatic malignancies after selective internal radiotherapy. Cancer Immunol Immunother. 2018;67(5):843–53. https://doi.org/10.1007/s00262-018-2141-0.

    CAS  Article  PubMed  Google Scholar 

  3. 3.

    Estrade F, Lescuré C, Muzellec L, et al. Lymphocytes and neutrophil-to-lymphocyte ratio variations after selective internal radiation treatment for HCC: a retrospective cohort study. Cardiovasc Interv Radiol. 2020. https://doi.org/10.1007/s00270-020-02467-9.

    Article  Google Scholar 

  4. 4.

    Chew V, Lee YH, Pan L, et al. Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma. Gut. 2019;68(2):335–46. https://doi.org/10.1136/gutjnl-2017-315485.

    CAS  Article  PubMed  Google Scholar 

  5. 5.

    Craciun L, De Wind R, Demetter P, et al. Retrospective analysis of the immunogenic effects of intra-arterial locoregional therapies in hepatocellular carcinoma: a rationale for combining selective internal radiation therapy (SIRT) and immunotherapy. BMC Cancer. 2020;20(1):1–10. https://doi.org/10.1186/s12885-020-6613-1.

    CAS  Article  Google Scholar 

Download references

Funding

This study was not supported by any funding.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Bruno Sangro.

Ethics declarations

Conflict of interest

Manuel de la Torre-Aláez (MdTA) received grants from Bayer. Bruno Sangro (BS) has received consulting fees from Adaptimmune, AstraZeneca, Bayer Bristol-Myers Squibb, BTG, H3 Biomedicine, Ipsen, Lilly, Roche, and Sirtex Medical; speakers' fees from Bayer Bristol-Myers Squibb, Ipsen, Lilly, and Sirtex Medical; and research funding from Bristol-Myers Squibb and Sirtex Medical.

Ethical Aproval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

For this type of study, informed consent is not required.

Consent for Publication

For this type of study, consent for publication is not required.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

de la Torre-Aláez, M., Sangro, B. Lymphocytes, Neutrophils and the Response to Selective Internal Radiation Therapy: More Questions than Answers Yet. Cardiovasc Intervent Radiol (2020). https://doi.org/10.1007/s00270-020-02556-9

Download citation