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Drug Release Property of Lipiodol Emulsion Formed by Glass Membrane Emulsification Device for Transarterial Chemoembolization

  • Laboratory Investigation
  • Interventional Oncology
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate physiochemical characteristics of emulsions formed by a modified emulsification device and to compare in vitro drug release properties of ethiodized oil (Lipiodol)-drug solution emulsion formed by the device and a 3-way-stopcock for conventional transarterial chemoembolization.

Materials and Methods

A V-shaped pumping emulsification device with a 100-μm-micropore glass membrane was developed to reduce the resistance of pumping. Epirubicin solution was mixed with Lipiodol (ratio 1:2) with pumping exchanges through the device. The percentage of water-in-oil (W/O) and droplet size distribution and viscosity were evaluated. The in vitro drug release properties were compared between using the device and a 3-way-stopcock.

Results

Percentage of W/O was 98.45 ± 0.03%. The median droplet size was 22.58 ± 1.70 μm, and the viscosity was 143.70 ± 12.36 cP. The released epirubicin at 0 min was 1.73 ± 1.05% in the device, whereas 41.02 ± 7.27% in a 3-way-stopcock (P < 0.001). The half-life of release (t50%) of the device was significantly longer than that of a 3-way-stopcock (175 ± 25 vs. 8 ± 6 min, P < 0.001).

Conclusion

The V-shaped emulsification device with a 100-μm-micropore glass membrane can form nearly 100% W/O emulsion with homogenous droplet sizes. Emulsion formed by the device showed a slower epirubicin release property compared with that of a 3-way-stopcock.

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Acknowledgements

We thank Ms. Marian Pahud for advice in submitting this article.

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Authors and Affiliations

  1. Department of Radiology, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8522, Japan

    Toshihiro Tanaka, Hideyuki Nishiofuku, Tetsuya Masada, Yasushi Fukuoka, Takeshi Sato, Shota Tatsumoto, Takeshi Matsumoto, Nagaaki Marugami & Kimihiko Kichikawa

  2. SPG Technology Co., Ltd, Miyazaki, Japan

    Mitsuteru Fujihara

Authors
  1. Toshihiro Tanaka
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  2. Hideyuki Nishiofuku
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  3. Tetsuya Masada
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  4. Yasushi Fukuoka
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  5. Takeshi Sato
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  6. Shota Tatsumoto
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  7. Takeshi Matsumoto
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  8. Nagaaki Marugami
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  9. Mitsuteru Fujihara
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  10. Kimihiko Kichikawa
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Corresponding author

Correspondence to Toshihiro Tanaka.

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MF is an employee of SPG Technology Co., Ltd. The other authors have no conflicts of interest and financial disclosures to declare.

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Tanaka, T., Nishiofuku, H., Masada, T. et al. Drug Release Property of Lipiodol Emulsion Formed by Glass Membrane Emulsification Device for Transarterial Chemoembolization. Cardiovasc Intervent Radiol 43, 135–139 (2020). https://doi.org/10.1007/s00270-019-02311-9

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  • DOI: https://doi.org/10.1007/s00270-019-02311-9

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