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Development of Repeatable Microcatheter Access Port for Intra-arterial Therapy of Liver Cancer

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Abstract

Purpose

To develop an implantable port in which a microcatheter can be inserted for a combination therapy of repeated transarterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC) for advanced liver cancer.

Materials and Methods

The design of a currently used implantable port was modified. A funnel part was constructed in the port. The septum was punctured by a 20-gauge indwelling needle, and 2.0-Fr non-tapered microcatheter was inserted into the port. In the in vitro studies, the advance of a microcatheter out of the funnel part was evaluated via seven different septum puncture sites. A 5-Fr indwelling catheter connected to the port was placed in a vascular model, and a microcatheter catheterization was evaluated. In an in vivo study, the port–catheter system was implanted in the hepatic artery in a pig. A microcatheter was percutaneously inserted through the port into the hepatic arterial branches, and embolization was performed.

Results

In the in vitro studies, the microcatheter was smoothly advanced out of the port and catheterizations into the hepatic arteries were successful via all septum puncture sites. In the in vivo study, repeated selective embolization through the port was successfully conducted on 7, 14 and 21 days after the implantation.

Conclusion

The developed implantable port can be used for repeated catheter insertion into the hepatic artery. The combination of repeated TACE and HAIC could be possible using this device.

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Acknowledgements

We thank Dr. Shunsuke Shimamura and Dr. Terumasa Shimada, Veterinary Medical Center, Osaka Prefecture University, for support in this animal study. We thank Ms. Marian Pahud for advice in submitting this article. This work was supported by Grant-in-Aid for Scientific Research (C), 15K09967.

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Authors and Affiliations

  1. Department of Radiology, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8522, Japan

    Yasushi Fukuoka, Toshihiro Tanaka, Hideyuki Nishiofuku, Takeshi Sato, Tetsuya Masada, Shota Tatsumoto, Nagaaki Marugami & Kimihiko Kichikawa

  2. Department of Radiology, Minaminara Medical Center, Oyodo, Japan

    Hiroshi Sakaguchi

Authors
  1. Yasushi Fukuoka
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  2. Toshihiro Tanaka
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  3. Hideyuki Nishiofuku
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  4. Takeshi Sato
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  5. Tetsuya Masada
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  6. Shota Tatsumoto
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  7. Nagaaki Marugami
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  8. Hiroshi Sakaguchi
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  9. Kimihiko Kichikawa
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Corresponding author

Correspondence to Toshihiro Tanaka.

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Conflict of interest

All authors have no conflicts of interest and financial disclosures to declare.

Ethical Approval

All applicable institutional and national guidelines for the care and use of animals were followed.

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Fukuoka, Y., Tanaka, T., Nishiofuku, H. et al. Development of Repeatable Microcatheter Access Port for Intra-arterial Therapy of Liver Cancer. Cardiovasc Intervent Radiol 42, 298–303 (2019). https://doi.org/10.1007/s00270-018-2111-0

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  • DOI: https://doi.org/10.1007/s00270-018-2111-0

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